PMID- 34728239
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 204
IP  - Pt C
DP  - 2022 Mar
TI  - Environmental exposure to bisphenol analogues and unexplained recurrent 
      miscarriage: A case-control study.
PG  - 112293
LID - S0013-9351(21)01594-2 [pii]
LID - 10.1016/j.envres.2021.112293 [doi]
AB  - The use of bisphenol A (BPA) has been substantially limited since 2010 due to its 
      toxicity to human health. A group of bisphenol analogues that are structurally 
      similar to BPA have been developed as the alternatives and used widely. The 
      reproductive toxicity of these emerging chemicals has caused substantial concerns 
      in recent years. Whether bisphenol analogues affect miscarriage, especially 
      unexplained recurrent miscarriage (URM), remains to be explored. We conducted a 
      hospital-based, case-control study with 1180 URM cases and 571 controls in China 
      from 2014 to 2016. Concentrations of six bisphenol analogues (BPA, BPAF, BPAP, 
      BPB, BPP and BPS) were measured in the urine samples collected at median 
      intervals of 7.6 months after last miscarriage (interquartile ranges: 4.8, 14.7 
      months). Multiple logistic regression, Bayesian kernel machine regression (BKMR) 
      and quantile g-computation (q-gcomp) were used to assess the relationship of 
      bisphenol analogues with URM risk. We observed significantly higher levels of all 
      urinary bisphenols in the cases than the controls. After controlling for 
      potential confounders, bisphenol analogues were significantly associated with 
      increased odds of URM in varying degrees. A dose-response pattern was observed 
      for the associations of BPAF, BPAP and BPB quartiles with URM. The mixed exposure 
      of six bisphenol analogues was positively associated with the risk of URM 
      (adjusted odds ratio (aOR) = 1.25; 1.11-1.42), which was mainly driven by BPAP 
      (60.1%), BPAF (25.1%) and BPA (14.8%). After age stratification, the risks tended 
      to be higher in women aged 30 years or older, compared to women <30 years. Our 
      large case-control study indicates that environmental exposure to bisphenol 
      analogues is associated with an increased risk of URM. Older women may be more 
      vulnerable to the insult.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Ao, Junjie
AU  - Ao J
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      200092, China.
FAU - Huo, Xiaona
AU  - Huo X
AD  - Obstetrics Department, International Peace Maternity and Child Health Hospital of 
      China, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
FAU - Zhang, Jiangtao
AU  - Zhang J
AD  - Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong 
      University, Jinan, 250001, China.
FAU - Mao, Yuchan
AU  - Mao Y
AD  - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of 
      Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, 310006, China.
FAU - Li, Guohua
AU  - Li G
AD  - Department of Reproductive Immunology, Shanghai First Maternity and Infant 
      Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
FAU - Ye, Jiangfeng
AU  - Ye J
AD  - Department of Clinical Epidemiology, Institute of Obstetrics and Gynecology, 
      Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200011, China.
FAU - Shi, Yuhua
AU  - Shi Y
AD  - Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong 
      University, Jinan, 250001, China.
FAU - Jin, Fan
AU  - Jin F
AD  - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of 
      Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, 310006, China. Electronic address: jinfan@zju.edu.cn.
FAU - Bao, Shihua
AU  - Bao S
AD  - Department of Reproductive Immunology, Shanghai First Maternity and Infant 
      Hospital, Tongji University School of Medicine, Shanghai, 201204, China. 
      Electronic address: baoshihua@tongji.edu.cn.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      200092, China; School of Public Health, Shanghai Jiao Tong University, Shanghai, 
      200025, China. Electronic address: junjimzhang@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211030
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - *Abortion, Habitual/chemically induced
MH  - Adult
MH  - Aged
MH  - Bayes Theorem
MH  - *Benzhydryl Compounds/toxicity
MH  - Case-Control Studies
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Phenols
MH  - Pregnancy
OTO - NOTNLM
OT  - Bisphenol
OT  - Environmental endocrine disruptor
OT  - Environmental epidemiology
OT  - Recurrent spontaneous abortion
OT  - Substitute
EDAT- 2021/11/04 06:00
MHDA- 2022/04/01 06:00
CRDT- 2021/11/03 05:53
PHST- 2021/07/22 00:00 [received]
PHST- 2021/10/24 00:00 [revised]
PHST- 2021/10/25 00:00 [accepted]
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/11/03 05:53 [entrez]
AID - S0013-9351(21)01594-2 [pii]
AID - 10.1016/j.envres.2021.112293 [doi]
PST - ppublish
SO  - Environ Res. 2022 Mar;204(Pt C):112293. doi: 10.1016/j.envres.2021.112293. Epub 
      2021 Oct 30.