PMID- 34728301
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 193
IP  - Pt A
DP  - 2021 Dec 15
TI  - Synthesis, characterization, in vitro antioxidant and hypoglycemic activities of 
      selenium nanoparticles decorated with polysaccharides of Gracilaria 
      lemaneiformis.
PG  - 923-932
LID - S0141-8130(21)02355-2 [pii]
LID - 10.1016/j.ijbiomac.2021.10.189 [doi]
AB  - Under a simple redox system of selenite and ascorbic acid, we used Gracilaria 
      lemaneiformis polysaccharides (GLPs) as a stabilizer and dispersing agent to 
      generate well-dispersed and stable selenium nanoparticles (SeNPs). The size, 
      stability, morphology and physicochemical properties of GLPs-SeNPs were 
      characterized by dynamic light scattering (DLS), scanning electron microscopy 
      (SEM), transmission electron microscopy (TEM), Ultraviolet-visible spectroscopy 
      (UV-vis), Fourier transform infrared (FT-IR) spectra, energy dispersive X-ray 
      (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), 
      Thermogravimetric (TG). The results showed that orange-red, amorphous, 
      zero-valent and spherical GLPs-SeNPs with mean diameter of approximately 92.5 nm 
      were successfully prepared, which exhibited good storage stability at 4  degrees C and 
      remaining highly stable at different ion strengths and pH. The 
      2,2-diphenyl-1-pycrylhydrazyl (DPPH), 
      2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) and superoxide anion 
      radical (O(2)(*-)) radical scavenging ability of GLPs-SeNPs were higher than 
      those of bare SeNPs, GLPs and sodium selenite (Na(2)SeO(3)), and could reach 
      103.41%, 94.23%, 86% at a concentration of 1.5 mg/mL, respectively. Besides, 
      GLPs-SeNPs also showed higher inhibitory effects on alpha-amylase and alpha-glucosidase. 
      In vitro cytotoxicity assay and hemolysis activity examinations indicated that 
      GLPs-SeNPs have excellent biocompatibility. Therefore, the GLPs-SeNPs might be 
      used as a potential antioxidant agent and antidiabetic agent for food and medical 
      applications.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Tang, Li
AU  - Tang L
AD  - College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 
      China.
FAU - Luo, Xiaomin
AU  - Luo X
AD  - College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 
      China.
FAU - Wang, Meiyuan
AU  - Wang M
AD  - College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 
      China.
FAU - Wang, Zhong
AU  - Wang Z
AD  - Yunfu Traditional Chinese Medicine Hospital, Yunfu, Guangdong, China.
FAU - Guo, Juan
AU  - Guo J
AD  - College of Food Science, Guangdong Pharmaceutical University, Zhongshan, 
      Guangdong, China.
FAU - Kong, Fansheng
AU  - Kong F
AD  - College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 
      China.
FAU - Bi, Yongguang
AU  - Bi Y
AD  - College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 
      China. Electronic address: biyongguang2002@163.com.
LA  - eng
PT  - Journal Article
DEP - 20211030
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antioxidants)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Polysaccharides)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - *Antioxidants/chemistry/pharmacology
MH  - Gracilaria/*metabolism
MH  - *Hypoglycemic Agents/chemistry/pharmacology
MH  - Mice
MH  - Nanoparticles/*chemistry
MH  - *Polysaccharides/chemistry/pharmacology
MH  - RAW 264.7 Cells
MH  - *Selenium/chemistry/pharmacology
OTO - NOTNLM
OT  - Antioxidant activity
OT  - Characterization
OT  - Gracilaria lemaneiformis polysaccharides
OT  - Hypoglycemic activity
OT  - Selenium nanoparticles
OT  - Stability
EDAT- 2021/11/04 06:00
MHDA- 2021/12/21 06:00
CRDT- 2021/11/03 05:54
PHST- 2021/08/10 00:00 [received]
PHST- 2021/10/16 00:00 [revised]
PHST- 2021/10/26 00:00 [accepted]
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/11/03 05:54 [entrez]
AID - S0141-8130(21)02355-2 [pii]
AID - 10.1016/j.ijbiomac.2021.10.189 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2021 Dec 15;193(Pt A):923-932. doi: 
      10.1016/j.ijbiomac.2021.10.189. Epub 2021 Oct 30.