PMID- 34729143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 2040-6223 (Print)
IS  - 2040-6231 (Electronic)
IS  - 2040-6223 (Linking)
VI  - 12
DP  - 2021
TI  - Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral 
      neuropathy in patients with type-2 diabetes.
PG  - 20406223211041936
LID - 10.1177/20406223211041936 [doi]
LID - 20406223211041936
AB  - BACKGROUND: Diabetic peripheral neuropathy (DPN), the most common microvascular 
      complication of type-2 diabetes mellitus (T2DM), results in nontraumatic 
      lower-limb amputations. When DPN is not detected early, disease progression is 
      irreversible. Thus, biomarkers for diagnosing DPN are needed. METHODS: We 
      analyzed three data sets of T2DM DPN: two for mouse models (GSE70852 and 
      GSE34889) and one for a human model (GSE24290). We found common differentially 
      expressed genes (DEGs) in the two mouse data sets and validated them in the human 
      data set. To identify the phenotypic function of the DEGs, we overexpressed them 
      in zebrafish embryos. Clinical information and serum samples of T2DM patients 
      with and without DPN were obtained from the Korea Biobank Network. To assess the 
      plausibility of DEGs as biomarkers of DPN, we performed an enzyme-linked 
      immunosorbent assay. RESULTS: Among the DEGs, only NPY and SLPI were validated in 
      the human data set. As npy is conserved in zebrafish, its mRNA was injected into 
      zebrafish embryos, and it was observed that the branches of the central nervous 
      system became thicker and the number of dendritic branches increased. Baseline 
      characteristics between T2DM patients with and without DPN did not differ, except 
      for the sex ratio. The mean serum NPY level was higher in T2DM patients with DPN 
      than in those without DPN (p = 0.0328), whereas serum SLPI levels did not differ 
      (p = 0.9651). CONCLUSION: In the pathogenesis of DPN, NPY may play a protective 
      role in the peripheral nervous system and may be useful as a biomarker for 
      detecting T2DM DPN.
CI  - (c) The Author(s), 2021.
FAU - Cho, Noo Ree
AU  - Cho NR
AD  - Department of Anesthesiology and Pain Medicine, Gachon University Gil Medical 
      Center, Incheon, Republic of Korea.
FAU - Yu, Yeuni
AU  - Yu Y
AD  - Biomedical Research Institute, Pusan National University Hospital, Busan, 
      Republic of Korea.
FAU - Oh, Chang-Kyu
AU  - Oh CK
AD  - Center for Genomic Integrity, Institute for Basic Science (IBS), Ulsan, Republic 
      of Korea.
FAU - Ko, Dai Sik
AU  - Ko DS
AD  - Division of Vascular Surgery, Department of Surgery, Gachon University Gil 
      Medical Center, Incheon, Republic of Korea.
FAU - Myung, Kyungjae
AU  - Myung K
AD  - Department of Anatomy, School of Medicine, Inje University, Busan, Republic of 
      Korea.
FAU - Lee, Yoonsung
AU  - Lee Y
AD  - Department of Anatomy, School of Medicine, Inje University, Busan, Republic of 
      Korea.
FAU - Na, Hee Sam
AU  - Na HS
AD  - Department of Oral Microbiology, School of Dentistry, Pusan National University, 
      Yangsan 50612, Republic of Korea.
FAU - Kim, Yun Hak
AU  - Kim YH
AUID- ORCID: 0000-0002-9796-8266
AD  - Departments of Anatomy and Biomedical Informatics, School of Medicine, Pusan 
      National University, Yangsan 50612, Republic of Korea. Biomedical Research 
      Institute, Pusan National University Hospital, Busan, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - United States
TA  - Ther Adv Chronic Dis
JT  - Therapeutic advances in chronic disease
JID - 101532140
PMC - PMC8438932
OTO - NOTNLM
OT  - biomarker
OT  - diabetic peripheral neuropathy
OT  - neuropeptide Y
OT  - type-2 diabetes mellitus
OT  - zebrafish
COIS- Conflict of interest statement: The authors declared no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2021/11/04 06:00
MHDA- 2021/11/04 06:01
PMCR- 2021/09/08
CRDT- 2021/11/03 06:56
PHST- 2021/05/18 00:00 [received]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/11/03 06:56 [entrez]
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2021/11/04 06:01 [medline]
PHST- 2021/09/08 00:00 [pmc-release]
AID - 10.1177_20406223211041936 [pii]
AID - 10.1177/20406223211041936 [doi]
PST - epublish
SO  - Ther Adv Chronic Dis. 2021 Sep 8;12:20406223211041936. doi: 
      10.1177/20406223211041936. eCollection 2021.