PMID- 34729226 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220428 IS - 2080-4806 (Print) IS - 2080-4873 (Electronic) IS - 2080-4806 (Linking) VI - 74 IP - 3 DP - 2021 TI - Has the COVID-19 outbreak changed the way we are treating prostate cancer? An EAU - YAU Prostate Cancer Working Group multi-institutional study. PG - 362-365 LID - 10.5173/ceju.2021.0211 [doi] AB - INTRODUCTION: The COVID-19 outbreak has become the dominant issue throughout the world whilst the governments, nations and health services are trying to deal with its impact. The aim of our study is to assess the impact of COVID-19 on patients treated with radical prostatectomy (RP) for prostate cancer (PCa) at European referral centers in terms of surgical volume (SV), waiting list meant as time from biopsy to surgery (WL) and risk of adverse pathologic findings at RP due to the selection of men with more adverse disease characteristics at final pathology. MATERIAL AND METHODS: Consecutive patients with a diagnosis of histologically proven PCa treated with RP between March 2020 (WHO declaration of pandemic) and December 2020 were identified. Patients with metastatic disease not eligible to local treatment and recurrent prostate cancer after RP or RT were excluded. Patients treated at the same institutions between March 2019 and December 2019 were considered as the control group. Multivariable logistic regression analysis tested the impact of the COVID-19 outbreak on the risk of adverse pathologic findings at RP after adjusting for confounders. The percentage change of SV and WL was assessed comparing the months of pandemic with the equivalent timespan of the previous year. RESULTS: A total of 2,574 patients treated with RP (927 cases and 1647 controls) were identified in 8 European tertiary referral centers. At multivariable analysis patients who were treated during the pandemic had higher risk of extra prostatic disease (OR:1.35, p = 0.038) and lymph node invasion (LNI) (OR:1.72, p = 0.048). An average 23% reduction of the SV with the equivalent timespan of the previous year allowed an illusory reduction of the WL after the peak gained during the first wave of COVID-19. CONCLUSIONS: Our results showed that the COVID-19 outbreak resulted in a delay in the administration of curative-intent therapies in patients with localized PCa. This, in turn, resulted in a stage migration phenomenon with a potential impact on oncologic control. CI - Copyright by Polish Urological Association. FAU - Zattoni, Fabio AU - Zattoni F AD - Urology Clinic, Academical Medical Centre Hospital, Udine, Italy. AD - Department of Surgical, Oncological and Gastroenterological Sciences-Urological Clinic, University of Padua, Padua, Italy. FAU - Marra, Giancarlo AU - Marra G AD - Department of Urology, Institut Mutualiste Montsouris, Paris, France. FAU - Kretschmer, Alexander AU - Kretschmer A AD - Department of Urology, Ludwig-Maximilians University of Munich, Munich, Germany. FAU - Preisser, Felix AU - Preisser F AD - Department of Urology, University Hospital Frankfurt, Frankfurt, Germany. FAU - Tilki, Derya AU - Tilki D AD - Martini-Klinik Prostate Cancer Center, and Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. FAU - Kesch, Claudia AU - Kesch C AD - Department of Urology, University Hospital Essen, Essen, Germany. FAU - Radtke, Jan Philipp AU - Radtke JP AD - Department of Urology, University Hospital Essen, Essen, Germany. FAU - Hoffmann, Nils AU - Hoffmann N AD - Department of Urology, University Hospital Essen, Essen, Germany. FAU - Morlacco, Alessandro AU - Morlacco A AD - Department of Surgical, Oncological and Gastroenterological Sciences-Urological Clinic, University of Padua, Padua, Italy. FAU - Dal Moro, Fabrizio AU - Dal Moro F AD - Department of Surgical, Oncological and Gastroenterological Sciences-Urological Clinic, University of Padua, Padua, Italy. FAU - Soeterik, Timo F W AU - Soeterik TFW AD - Department of Urology, St Antonius Hospital, Utrecht, The Netherlands. FAU - van den Bergh, Roderick C N AU - van den Bergh RCN AD - Department of Urology, St Antonius Hospital, Utrecht, The Netherlands. FAU - Barletta, Francesco AU - Barletta F AD - Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. FAU - Briganti, Alberto AU - Briganti A AD - Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. FAU - Montorsi, Francesco AU - Montorsi F AD - Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. FAU - Gandaglia, Giorgio AU - Gandaglia G AD - Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. LA - eng PT - Journal Article DEP - 20210918 PL - Poland TA - Cent European J Urol JT - Central European journal of urology JID - 101587101 PMC - PMC8552935 OTO - NOTNLM OT - COVID-19 OT - prostate cancer OT - radical prostatectomy OT - stage migration OT - surgical volume OT - waiting list COIS- The authors declare no conflicts of interest. EDAT- 2021/11/04 06:00 MHDA- 2021/11/04 06:01 PMCR- 2021/01/01 CRDT- 2021/11/03 06:57 PHST- 2021/08/25 00:00 [received] PHST- 2021/09/02 00:00 [revised] PHST- 2021/09/05 00:00 [accepted] PHST- 2021/11/03 06:57 [entrez] PHST- 2021/11/04 06:00 [pubmed] PHST- 2021/11/04 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 0211 [pii] AID - 10.5173/ceju.2021.0211 [doi] PST - ppublish SO - Cent European J Urol. 2021;74(3):362-365. doi: 10.5173/ceju.2021.0211. Epub 2021 Sep 18.