PMID- 34730401
OWN - NLM
STAT- MEDLINE
DCOM- 20220308
LR  - 20230713
IS  - 1478-7083 (Electronic)
IS  - 0035-8843 (Print)
IS  - 0035-8843 (Linking)
VI  - 104
IP  - 3
DP  - 2022 Mar
TI  - Heller myotomy versus Heller myotomy with fundoplication in patients with 
      achalasia: a systematic review and meta-analysis.
PG  - 158-164
LID - 10.1308/rcsann.2020.7123 [doi]
AB  - INTRODUCTION: Heller myotomy (HM) remains the gold standard procedure for 
      achalasia. The addition of different types of fundoplication to HM has been 
      debated in several studies. Given the contradictory reports, this meta-analysis 
      was undertaken to compare different outcomes after HM and HM with fundoplication 
      (HMF). METHODS: An electronic search was performed among five major databases 
      (PubMed, Ovid, Scopus, Cochrane Library, Google Scholar) from inception to 
      October 2019, identifying all randomised and non-randomised studies comparing HM 
      with HMF. Two authors searched electronic databases using the keywords 
      'achalasia' AND 'dysphagia' AND 'gastroesophageal reflux' and all data were 
      pooled for random-effects meta-analysis. The primary and secondary outcomes were 
      gastroesophageal reflux and dysphagia, respectively. RESULTS: A total of six 
      studies were included and involved 576 patients comparing HM and HMF. There was 
      no statistically significant difference between gastroesophageal reflux in the HM 
      vs HMF group (21.3% vs 22.9%, RR 1.32, 95% CI 0.60-2.88, p = 0.49). There was a 
      slightly higher incidence of dysphagia observed in HM vs HMF (14.8% vs 10.8%, RR 
      1.54, 95% CI 0.98-2.41, p = 0.06). CONCLUSIONS: There was no statistically 
      significant difference in long-term outcomes between a group of patients 
      undergoing HM and a group who underwent HM with fundoplication.
FAU - Santoro, G
AU  - Santoro G
AD  - Warrington and Halton Teaching Hospitals NHS Foundation Trust, UK.
FAU - Sheriff, N
AU  - Sheriff N
AD  - Warrington and Halton Teaching Hospitals NHS Foundation Trust, UK.
FAU - Noronha, J
AU  - Noronha J
AD  - Aintree University Hospital, UK.
FAU - Nunes, Q M
AU  - Nunes QM
AD  - University of Liverpool, UK.
FAU - Tandon, A
AU  - Tandon A
AD  - Warrington and Halton Teaching Hospitals NHS Foundation Trust, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20211103
PL  - England
TA  - Ann R Coll Surg Engl
JT  - Annals of the Royal College of Surgeons of England
JID - 7506860
SB  - IM
MH  - Aged
MH  - Deglutition Disorders/epidemiology
MH  - *Esophageal Achalasia/epidemiology/surgery
MH  - Female
MH  - *Fundoplication/adverse effects/statistics & numerical data
MH  - *Heller Myotomy/adverse effects/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/epidemiology
MH  - Treatment Outcome
PMC - PMC10335085
OTO - NOTNLM
OT  - Achalasia
OT  - Fundoplication
OT  - Heller myotomy
OT  - Meta-analysis
EDAT- 2021/11/04 06:00
MHDA- 2022/03/09 06:00
PMCR- 2022/03/01
CRDT- 2021/11/03 12:11
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2022/03/09 06:00 [medline]
PHST- 2021/11/03 12:11 [entrez]
PHST- 2022/03/01 00:00 [pmc-release]
AID - rcsann.2020.7123 [pii]
AID - 10.1308/rcsann.2020.7123 [doi]
PST - ppublish
SO  - Ann R Coll Surg Engl. 2022 Mar;104(3):158-164. doi: 10.1308/rcsann.2020.7123. 
      Epub 2021 Nov 3.