PMID- 34730891
OWN - NLM
STAT- MEDLINE
DCOM- 20211105
LR  - 20220531
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 62
IP  - 5
DP  - 2021 Oct 31
TI  - SIRT1 and Klotho expression in the heart and kidneys of rats with acute and 
      chronic renovascular hypertension.
PG  - 504-512
AB  - AIM: To evaluate Klotho and SIRT1 expression in the heart and kidneys of rats 
      with acute and chronic renovascular hypertension. METHODS: Four and sixteen weeks 
      after the induction of renovascular hypertension by clipping the left renal 
      artery, systemic blood pressure, serum angiotensin II level, and the expression 
      of Klotho and SIRT1 proteins and oxidative stress indices in the heart and 
      kidneys were assessed. RESULTS: SIRT1 level was significantly reduced in the 
      ischemic (left) kidney in acute and chronic phases of hypertension. In the heart, 
      it decreased in the acute phase, but increased in the chronic phase. Klotho 
      levels in the heart and kidneys did not change significantly in either 
      hypertension phase. Superoxide dismutase (SOD) activity in the heart 
      significantly decreased, and SOD, total antioxidant capacity, and malondialdehyde 
      in the ischemic kidney significantly increased during the development of 
      hypertension. Serum angiotensin II level significantly increased in the acute 
      phase of hypertension. CONCLUSION: Development of renovascular hypertension was 
      associated with a reduction of SIRT1 expression in the heart and ischemic kidney. 
      As angiotensin II and SIRT1 counteract each other's expression, a SIRT1 reduction 
      in the heart and kidney, along with the influence of systemic/local angiotensin 
      II, seems to be partly responsible for hypertension development. A combination of 
      SIRT1 agonists and angiotensin II antagonists may be considered for use in the 
      treatment of renovascular hypertension.
FAU - Yeganeh-Hajahmadi, Mahboobeh
AU  - Yeganeh-Hajahmadi M
FAU - Najafipour, Hamid
AU  - Najafipour H
AD  - Hamid Najafipour, Professor of Physiology, Cardiovascular Research Center, 
      Boulevard Jahad, Ebne Sina Avenue, Kerman, Iran, najafipourh@yahoo.co.uk.
FAU - Rostamzadeh, Farzaneh
AU  - Rostamzadeh F
FAU - Masoumi-Ardakani, Yaser
AU  - Masoumi-Ardakani Y
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.2.1.31 (Glucuronidase)
RN  - EC 3.2.1.31 (Klotho Proteins)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Angiotensin II
MH  - Animals
MH  - Blood Pressure
MH  - Glucuronidase
MH  - *Hypertension
MH  - *Hypertension, Renovascular
MH  - Kidney
MH  - Klotho Proteins
MH  - Rats
MH  - Sirtuin 1
PMC - PMC8596473
EDAT- 2021/11/04 06:00
MHDA- 2021/11/06 06:00
PMCR- 2021/10/01
CRDT- 2021/11/03 12:29
PHST- 2021/11/03 12:29 [entrez]
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2021/11/06 06:00 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - CroatMedJ_62_0504 [pii]
AID - 10.3325/cmj.2021.62.504 [doi]
PST - ppublish
SO  - Croat Med J. 2021 Oct 31;62(5):504-512. doi: 10.3325/cmj.2021.62.504.