PMID- 34731995
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211104
IS  - 1267-8694 (Print)
IS  - 1267-8694 (Linking)
VI  - 10
IP  - 4
DP  - 2006 Aug 1
TI  - [Intra cellular trafficking of influenza virus proteins].
PG  - 301-309
LID - 10.1684/vir.2011.7062 [doi]
AB  - Influenza virus is a negative strand RNA virus and is one of the rare RNA viruses 
      to replicate in the nucleus. The viral RNA is associated with 4 viral proteins to 
      make ribonucleoprotein particles (RNPs). After cell entry the RNPs are 
      dissociated from the viral matrix protein in the low pH of the endosome and are 
      actively imported into the cell nucleus. After translation of viral mRNAs, the 
      proteins necessary for the assembly of new RNPs (the nucleoprotein and the three 
      subunits of the polymerase complex) are also imported into the nucleus. Apart 
      from these four proteins, part of the newly made matrix protein is also imported 
      and the NEP (nuclear export protein) enters the nucleus probably through 
      diffusion. The nuclear localisation signals on all these viral proteins and their 
      interaction with the cellular transport system are discussed. In the nucleus, the 
      matrix protein binds to the newly assembled RNPs and NEP then binds to the matrix 
      protein. NEP contains the nuclear export signal necessary for transport of the 
      RNPs to the cytoplasm for the budding of new virus particles. There appears to be 
      a intricate ballet in exposing and hiding nuclear transport signals which leads 
      to a unidirectional transport of the RNPs to the nucleus at the start of the 
      infection process and an opposite unidirectional export of RNPs at the end of the 
      infection.
FAU - Akarsu, H
AU  - Akarsu H
AD  - Institut de virologie moleculaire et structurale, FRE 2854 CNRS-UJF, c/o EMBL, 
      BP181, 38042 Grenoble Cedex 9.
FAU - Boulo, S
AU  - Boulo S
AD  - Institut de virologie moleculaire et structurale, FRE 2854 CNRS-UJF, c/o EMBL, 
      BP181, 38042 Grenoble Cedex 9.
FAU - Ruigrok, R W H
AU  - Ruigrok RWH
AD  - Institut de virologie moleculaire et structurale, FRE 2854 CNRS-UJF, c/o EMBL, 
      BP181, 38042 Grenoble Cedex 9.
FAU - Baudin, F
AU  - Baudin F
AD  - Institut de virologie moleculaire et structurale, FRE 2854 CNRS-UJF, c/o EMBL, 
      BP181, 38042 Grenoble Cedex 9.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le trafic nucleocytoplasmique des proteines et des ribonucleoproteines du virus 
      de la grippe.
PL  - France
TA  - Virologie (Montrouge)
JT  - Virologie (Montrouge, France)
JID - 9802575
SB  - IM
OTO - NOTNLM
OT  - influenza virus
OT  - nuclear transport
OT  - replication
OT  - virus-host interactions
EDAT- 2006/08/01 00:00
MHDA- 2006/08/01 00:01
CRDT- 2021/11/04 01:01
PHST- 2021/11/04 01:01 [entrez]
PHST- 2006/08/01 00:00 [pubmed]
PHST- 2006/08/01 00:01 [medline]
AID - vir.2011.7062 [pii]
AID - 10.1684/vir.2011.7062 [doi]
PST - ppublish
SO  - Virologie (Montrouge). 2006 Aug 1;10(4):301-309. doi: 10.1684/vir.2011.7062.