PMID- 34732466
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 207
IP  - 11
DP  - 2021 Dec 1
TI  - Vps33B in Dendritic Cells Regulates House Dust Mite-Induced Allergic Lung 
      Inflammation.
PG  - 2649-2659
LID - 10.4049/jimmunol.2100502 [doi]
AB  - Dendritic cells (DCs) are the most specialized APCs that play a critical role in 
      driving Th2 differentiation, but the mechanism is not fully understood. Here we 
      show that vacuolar protein sorting 33B (Vps33B) plays an important role in this 
      process. Mice with Vps33b-specific deletion in DCs, but not in macrophages or T 
      cells, were more susceptible to Th2-mediated allergic lung inflammation than 
      wild-type mice. Deletion of Vps33B in DCs led to enhanced CD4(+) T cell 
      proliferation and Th2 differentiation. Moreover, Vps33B specifically restrained 
      reactive oxygen species production in conventional DC1s to inhibit Th2 responses 
      in vitro, whereas Vps33B in monocyte-derived DCs and conventional DC2s was 
      dispensable for Th2 development in asthma pathogenesis. Taken together, our 
      results identify Vps33B as an important molecule that mediates the cross-talk 
      between DCs and CD4(+) T cells to further regulate allergic asthma pathogenesis.
CI  - Copyright (c) 2021 by The American Association of Immunologists, Inc.
FAU - Ma, Jingyu
AU  - Ma J
AUID- ORCID: 0000-0003-0207-8015
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Han, Miaomiao
AU  - Han M
AUID- ORCID: 0000-0002-6941-5816
AD  - ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan 
      University, Shanghai, China.
FAU - Yang, Di
AU  - Yang D
AUID- ORCID: 0000-0003-2625-3746
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zheng, Tingting
AU  - Zheng T
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
AD  - Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong 
      Medical University, Dongguan, Guangdong, China; and.
FAU - Hu, Ran
AU  - Hu R
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong 
      Medical University, Dongguan, Guangdong, China; and.
FAU - Ye, Youqiong
AU  - Ye Y
AUID- ORCID: 0000-0001-8332-4710
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Liu, Junling
AU  - Liu J
AUID- ORCID: 0000-0002-2510-790X
AD  - Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell 
      Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Huang, Gonghua
AU  - Huang G
AUID- ORCID: 0000-0003-1579-5478
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China; 
      gonghua.huang@gdmu.edu.cn.
AD  - Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong 
      Medical University, Dongguan, Guangdong, China; and.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211103
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (VPS33B protein, mouse)
RN  - 0 (Vesicular Transport Proteins)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Hypersensitivity/*immunology
MH  - Inflammation/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Pyroglyphidae/*immunology
MH  - Vesicular Transport Proteins/*immunology
EDAT- 2021/11/05 06:00
MHDA- 2021/11/30 06:00
CRDT- 2021/11/04 05:37
PHST- 2021/05/27 00:00 [received]
PHST- 2021/09/27 00:00 [accepted]
PHST- 2021/11/05 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2021/11/04 05:37 [entrez]
AID - jimmunol.2100502 [pii]
AID - 10.4049/jimmunol.2100502 [doi]
PST - ppublish
SO  - J Immunol. 2021 Dec 1;207(11):2649-2659. doi: 10.4049/jimmunol.2100502. Epub 2021 
      Nov 3.