PMID- 34732547
OWN - NLM
STAT- MEDLINE
DCOM- 20211105
LR  - 20220716
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 42
IP  - 11
DP  - 2021 Nov
TI  - Routine laboratory parameters predict serious outcome as well as length of 
      hospital stay in COVID-19.
PG  - 1165-1172
LID - 10.15537/smj.2021.42.11.20210429 [doi]
AB  - OBJECTIVES: To validate C-reactive protein (CRP), red cell distribution width 
      (RDW), and neutrophil lymphocyte ratio (NLR) for both serious outcomes and length 
      of hospital stay (LOS) among hospitalized coronavirus disease-19 (COVID-19) 
      patients. METHODS: Laboratory data of adult COVID-19 patients (n=74) was 
      collected in this retrospective cohort. Logistic regression was employed for risk 
      factor evaluation and receiver operating curve was used for comparison of these 
      risk factors for the prediction of serious outcome. Multiple regression was 
      applied to determine the association between routine analytes and LOS. RESULTS: 
      Higher levels of CRP (3 times), white blood cells (20%), and neutrophil counts 
      (40%) were seen in the serious category. Odds ratio for CRP for the serious 
      outcome was 1.052 (p=0.007) and RDW for the serious outcome was 1.218 (p=0.040) 
      in unadjusted model and odds ratio for CRP for the serious outcome was 1.048 
      (p=0.024) and for RDW 1.286 (p=0.023) in adjusted model. In a multivariate 
      regression analysis for the LOS of the unadjusted models consisting of NLR, 
      monocyte lymphocyte ratio (MLR) and platelet lymphocyte ratio (PLR), the beta 
      coefficients (BC) for the CRP were 0.006 (NLR), 0.005 (MLR) and 0.006 (PLR), 
      whereas -0.029 (NLR), -0.034 (MLR) and -0.027 (PLR) were BCs for mean corpuscular 
      hemoglobin concentration (MCHC). Additionally, in adjusted models, the BCs for 
      MCHC were -0.044 (NLR), -0.047 (MLR) and -0.043 (PLR). However, the CRP was 
      consistent with 0.004 (BC) in all models. CONCLUSION: We observed that CRP is a 
      better predictor than RDW and NLR for serious outcome among COVID-19 patients. 
      Besides, CRP was positively, whereas MCHC was negatively associated with LOS.
CI  - Copyright: (c) Saudi Medical Journal.
FAU - Jeraiby, Mohammed A
AU  - Jeraiby MA
AD  - From the Department of Medical Biochemistry (Jeraiby, Iqbal), Faculty of 
      Medicine, Jazan University, from the Department of Pulmonology (Hakamy, Albarqi, 
      Areda); and from the Department of Laboratory Medicine (Haddad), King Fahad 
      Central Hospital, Jazan, Kingdom of Saudi Arabia.
FAU - Hakamy, Majed I
AU  - Hakamy MI
AD  - From the Department of Medical Biochemistry (Jeraiby, Iqbal), Faculty of 
      Medicine, Jazan University, from the Department of Pulmonology (Hakamy, Albarqi, 
      Areda); and from the Department of Laboratory Medicine (Haddad), King Fahad 
      Central Hospital, Jazan, Kingdom of Saudi Arabia.
FAU - Albarqi, Mohammed B
AU  - Albarqi MB
AD  - From the Department of Medical Biochemistry (Jeraiby, Iqbal), Faculty of 
      Medicine, Jazan University, from the Department of Pulmonology (Hakamy, Albarqi, 
      Areda); and from the Department of Laboratory Medicine (Haddad), King Fahad 
      Central Hospital, Jazan, Kingdom of Saudi Arabia.
FAU - Areda, Rehab I
AU  - Areda RI
AD  - From the Department of Medical Biochemistry (Jeraiby, Iqbal), Faculty of 
      Medicine, Jazan University, from the Department of Pulmonology (Hakamy, Albarqi, 
      Areda); and from the Department of Laboratory Medicine (Haddad), King Fahad 
      Central Hospital, Jazan, Kingdom of Saudi Arabia.
FAU - Haddad, Moayad A
AU  - Haddad MA
AD  - From the Department of Medical Biochemistry (Jeraiby, Iqbal), Faculty of 
      Medicine, Jazan University, from the Department of Pulmonology (Hakamy, Albarqi, 
      Areda); and from the Department of Laboratory Medicine (Haddad), King Fahad 
      Central Hospital, Jazan, Kingdom of Saudi Arabia.
FAU - Iqbal, Johar
AU  - Iqbal J
AD  - From the Department of Medical Biochemistry (Jeraiby, Iqbal), Faculty of 
      Medicine, Jazan University, from the Department of Pulmonology (Hakamy, Albarqi, 
      Areda); and from the Department of Laboratory Medicine (Haddad), King Fahad 
      Central Hospital, Jazan, Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Blood Platelets
MH  - *COVID-19
MH  - Humans
MH  - *Laboratories
MH  - Length of Stay
MH  - Lymphocytes
MH  - Neutrophils
MH  - Prognosis
MH  - Retrospective Studies
MH  - SARS-CoV-2
PMC - PMC9149729
OTO - NOTNLM
OT  - C-reactive protein
OT  - COVID-19
OT  - Coronavirus
OT  - mean corpuscular hemoglobin concentration
OT  - neutrophil-lymphocyte-ratio
OT  - red cell distribution width
EDAT- 2021/11/05 06:00
MHDA- 2021/11/06 06:00
PMCR- 2021/11/01
CRDT- 2021/11/04 05:39
PHST- 2021/05/31 00:00 [received]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2021/11/04 05:39 [entrez]
PHST- 2021/11/05 06:00 [pubmed]
PHST- 2021/11/06 06:00 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - 42/11/1165 [pii]
AID - SaudiMedJ-42-1165 [pii]
AID - 10.15537/smj.2021.42.11.20210429 [doi]
PST - ppublish
SO  - Saudi Med J. 2021 Nov;42(11):1165-1172. doi: 10.15537/smj.2021.42.11.20210429.