PMID- 34733040
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211105
IS  - 0972-5229 (Print)
IS  - 1998-359X (Electronic)
IS  - 0972-5229 (Linking)
VI  - 25
IP  - 8
DP  - 2021 Aug
TI  - Clarithromycin-induced Seizures and Status Epilepticus.
PG  - 945-947
LID - 10.5005/jp-journals-10071-23900 [doi]
AB  - Clarithromycin is a commonly used antibiotic. Neuropsychiatric adverse effects 
      are recognized, but the occurrence of seizures and status epilepticus (SE) has 
      been rarely reported. We report the case of an elderly patient who developed 
      generalized tonic-clonic seizures (GTCS) followed by nonconvulsive status 
      epilepticus (NCSE), 2 days after starting clarithromycin. Other causes of 
      seizures were excluded by magnetic resonance imaging (MRI) of the brain, CSF 
      analysis, and routine laboratory studies, thus establishing the causal role of 
      clarithromycin. Clarithromycin was stopped and parenteral antiepileptic drugs 
      started, which controlled the status. In the elderly, symptoms like delirium, 
      drowsiness, confusion, or seizures can occur due to an underlying systemic 
      disease, brain pathology, or adverse effects of medications, all of which must be 
      correctly differentiated. This case illustrates the occurrence of seizures and SE 
      due to clarithromycin. Awareness about this possibility will help physicians 
      recognize and treat such situations promptly. How to cite this article: Seetharam 
      R, Iyer RB, Nooraine J, Ramachandran J. Clarithromycin-induced Seizures and 
      Status Epilepticus. Indian J Crit Care Med 2021;25(8):945-947.
CI  - Copyright (c) 2021; Jaypee Brothers Medical Publishers (P) Ltd.
FAU - Seetharam, Raghavendra
AU  - Seetharam R
AD  - Department of Neurology, Vikram Hospital, Bengaluru, Karnataka, India.
FAU - Iyer, Rajesh B
AU  - Iyer RB
AD  - Department of Neurology, Vikram Hospital, Bengaluru, Karnataka, India.
FAU - Nooraine, Javeria
AU  - Nooraine J
AD  - Department of Neurology, Vikram Hospital, Bengaluru, Karnataka, India.
FAU - Ramachandran, Jaychandran
AU  - Ramachandran J
AD  - Department of Neurology, Vikram Hospital, Bengaluru, Karnataka, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Crit Care Med
JT  - Indian journal of critical care medicine : peer-reviewed, official publication of 
      Indian Society of Critical Care Medicine
JID - 101208863
PMC - PMC8559746
OTO - NOTNLM
OT  - Adverse effects
OT  - Antibiotics
OT  - Clarithromycin
OT  - Neurotoxicity
OT  - Nonconvulsive status epilepticus
COIS- Source of support: Nil Conflict of interest: None
EDAT- 2021/11/05 06:00
MHDA- 2021/11/05 06:01
PMCR- 2021/08/01
CRDT- 2021/11/04 06:19
PHST- 2021/11/04 06:19 [entrez]
PHST- 2021/11/05 06:00 [pubmed]
PHST- 2021/11/05 06:01 [medline]
PHST- 2021/08/01 00:00 [pmc-release]
AID - 10.5005/jp-journals-10071-23900 [doi]
PST - ppublish
SO  - Indian J Crit Care Med. 2021 Aug;25(8):945-947. doi: 
      10.5005/jp-journals-10071-23900.