PMID- 34734242
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20221104
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Print)
IS  - 0021-8812 (Linking)
VI  - 99
IP  - 11
DP  - 2021 Nov 1
TI  - Thyroid hormone suppression in feeder pigs following polymicrobial or porcine 
      reproductive and respiratory syndrome virus-2 challenge.
LID - 10.1093/jas/skab325 [doi]
LID - skab325
AB  - Thyroid hormones are powerful regulators of growth, development, and basal 
      metabolic rate and can be dysregulated under conditions of severe stress or 
      illness. To understand the role of these hormones in porcine disease response, 
      serum samples were obtained from three batches of nursery-aged pigs (n = 208) 
      exposed to a natural polymicrobial disease challenge with an array of bacterial 
      and viral pathogens. Levels of total thyroxin (T4) and triiodothyronine (T3) 
      assessed in sera by radioimmunoassay, decreased significantly by 14 days 
      post-exposure (DPE). Levels of T3 partially rebounded by 48 DPE, while T4 levels 
      remain depressed. Post-exposure T3 and T4 levels were positively correlated with 
      acute and long-term average daily gain (ADG). Cross-sectional sampling of animals 
      maintained at the high health source farms, showed no equivalent change in either 
      hormone when managed under standard industrial conditions. To further elucidate 
      the effect of porcine reproductive and respiratory syndrome virus 
      (PRRSV)-infection on thyroid hormone levels, archived sera over 42 days post 
      inoculation (DPI) from nursery pigs (N = 190) challenged with one of two PRRSV2 
      strains by the PRRS Host Genetics Consortium were similarly assessed, with 
      animals selected in a two-by-two design, to investigate biological extremes in 
      ADG and viral load (VL). All animals showed a similar decrease in both thyroid 
      hormones reaching a minimum at 7 DPI and returning to near pre-challenge levels 
      by 42 DPI. Post-challenge T3 and T4 levels were significantly greater in high ADG 
      groups, with no significant association with VL or strain. The results of this 
      study demonstrate porcine susceptibility to thyroid disruption in response to 
      disease challenge and demonstrate a relationship between this response and growth 
      performance.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      American Society of Animal Science. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Pasternak, J Alex
AU  - Pasternak JA
AUID- ORCID: 0000-0001-8596-3057
AD  - Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
FAU - MacPhee, Daniel J
AU  - MacPhee DJ
AUID- ORCID: 0000-0001-5721-6185
AD  - Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK 
      S7N 5B4, Canada.
FAU - Lunney, Joan K
AU  - Lunney JK
AD  - USDA, ARS, BARC, Beltsville, MD 20705, USA.
FAU - Rowland, Raymond R R
AU  - Rowland RRR
AD  - College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA.
FAU - Dyck, Michael K
AU  - Dyck MK
AD  - Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB 
      T6G 2R3, Canada.
FAU - Fortin, Frederic
AU  - Fortin F
AD  - Centre de developpement du porc du Quebec Inc., Quebec City, QC G1V 4M6, Canada.
FAU - Dekkers, Jack C M
AU  - Dekkers JCM
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
FAU - Plastow, Graham S
AU  - Plastow GS
AUID- ORCID: 0000-0002-3774-3110
AD  - Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB 
      T6G 2R3, Canada.
FAU - Harding, John C S
AU  - Harding JCS
AD  - Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK 
      S7N 5B4, Canada.
CN  - PigGen Canada
LA  - eng
GR  - Ontario Pork Producers Marketing Board/
GR  - Natural Science and Engineering Research Council of Canada/
PT  - Journal Article
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Antibodies, Viral)
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral
MH  - Cross-Sectional Studies
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Swine
MH  - *Swine Diseases
MH  - Thyroid Hormones
MH  - Viral Load/veterinary
PMC - PMC8633620
OTO - NOTNLM
OT  - PRRSV
OT  - host-pathogen interaction
OT  - non-thyroidal illness syndrome
OT  - thyroid hormone
EDAT- 2021/11/05 06:00
MHDA- 2021/12/15 06:00
PMCR- 2022/11/03
CRDT- 2021/11/04 06:34
PHST- 2021/09/10 00:00 [received]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/11/05 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/11/04 06:34 [entrez]
PHST- 2022/11/03 00:00 [pmc-release]
AID - 6420436 [pii]
AID - skab325 [pii]
AID - 10.1093/jas/skab325 [doi]
PST - ppublish
SO  - J Anim Sci. 2021 Nov 1;99(11):skab325. doi: 10.1093/jas/skab325.