PMID- 34736717 OWN - NLM STAT- MEDLINE DCOM- 20211108 LR - 20211108 IS - 1873-3573 (Electronic) IS - 0039-9140 (Linking) VI - 237 DP - 2022 Jan 15 TI - Illicit drugs street samples and their cutting agents. The result of the GC-MS based profiling define the guidelines for sensors development. PG - 122904 LID - S0039-9140(21)00826-2 [pii] LID - 10.1016/j.talanta.2021.122904 [doi] AB - In this work, we have focused on the profiling of 5647 street samples covering marijuana, common and new recreational illicit drugs. All samples were analyzed using gas chromatography-mass spectrometry (GC-MS) technique. In total we have identified 53 illicit drugs with Delta-9-tetrahydrocannabinol (THC), amphetamine, N-ethylhexedrone, 3,4-methylenedioxy methamphetamine (MDMA), 4-chloromethcathinone (4-CMC), alpha-pyrrolidinoisohexaphenone (alpha-PHiP), cocaine, and 4-chloroethcathinone (4-CEC) being most commonly found and making 38.5, 17.8, 15.5, 8.0, 3.5, 2.7, 2.1, and 2.0% of the total studied pool, respectively. Except for methadone, all analyzed street samples were spiked with at least one cutting agent. Caffeine was the most frequently found adulterating addition present in around 33% (excluding marijuana) of the analyzed samples. Other identified cutting agents make an impressive group of more than 160 compounds. Finally, we have tabulated, illustrated, and discussed presented data in a view of smart and portable sensors development. CI - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Zubrycka, Anna AU - Zubrycka A AD - Laboratorium Badan Toksykologicznych Lab4Tox Sp. Z o.o., Sklodowskiej-Curie 55/61, 50-369, Wroclaw, Poland; Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland. FAU - Kwasnica, Andrzej AU - Kwasnica A AD - Laboratorium Badan Toksykologicznych Lab4Tox Sp. Z o.o., Sklodowskiej-Curie 55/61, 50-369, Wroclaw, Poland. FAU - Haczkiewicz, Monika AU - Haczkiewicz M AD - Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. FAU - Sipa, Karolina AU - Sipa K AD - Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland. FAU - Rudnicki, Konrad AU - Rudnicki K AD - Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland. FAU - Skrzypek, Slawomira AU - Skrzypek S AD - Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland. FAU - Poltorak, Lukasz AU - Poltorak L AD - Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland. Electronic address: lukasz.poltorak@chemia.uni.lodz.pl. LA - eng PT - Journal Article DEP - 20210928 PL - Netherlands TA - Talanta JT - Talanta JID - 2984816R RN - 0 (Illicit Drugs) RN - 44RAL3456C (Methamphetamine) RN - CK833KGX7E (Amphetamine) RN - I5Y540LHVR (Cocaine) SB - IM MH - Amphetamine/analysis MH - *Cocaine/analysis MH - Gas Chromatography-Mass Spectrometry MH - *Illicit Drugs MH - *Methamphetamine/analysis MH - Substance Abuse Detection OTO - NOTNLM OT - Amphetamine OT - Cocaine OT - GC-MS OT - Heroin OT - Narcotics OT - Sensors EDAT- 2021/11/06 06:00 MHDA- 2021/11/09 06:00 CRDT- 2021/11/05 05:39 PHST- 2021/08/16 00:00 [received] PHST- 2021/09/21 00:00 [revised] PHST- 2021/09/22 00:00 [accepted] PHST- 2021/11/05 05:39 [entrez] PHST- 2021/11/06 06:00 [pubmed] PHST- 2021/11/09 06:00 [medline] AID - S0039-9140(21)00826-2 [pii] AID - 10.1016/j.talanta.2021.122904 [doi] PST - ppublish SO - Talanta. 2022 Jan 15;237:122904. doi: 10.1016/j.talanta.2021.122904. Epub 2021 Sep 28.