PMID- 34736985
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 180
DP  - 2022 Jan
TI  - Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: 
      Construction and preclinical demonstration.
PG  - 114031
LID - S0169-409X(21)00424-5 [pii]
LID - 10.1016/j.addr.2021.114031 [doi]
AB  - Dynamic drug delivery systems (DDSs) have the ability of transforming their 
      morphology and functionality in response to the biological microenvironments at 
      the disease site and/or external stimuli, show spatio-temporally controllable 
      drug delivery, and enhance the treatment efficacy. Due to the large surface area 
      and modification flexibility, two-dimensional (2D) inorganic nanomaterials are 
      being increasingly exploited for developing intelligent DDSs for biomedical 
      applications. In this review, we summarize the engineering methodologies used to 
      construct transformable 2D DDSs, including changing compositions, creating 
      defects, and surface dot-coating with polymers, biomolecules, or nanodots. Then 
      we present and discuss dynamic inorganic 2D DDSs whose transformation is driven 
      by the diseased characteristics, such as pH gradient, redox, hypoxia, and enzyme 
      in the tumor microenvironment as well as the external stimuli including light, 
      magnetism, and ultrasound. Finally, the limitations and challenges of current 
      transformable inorganic DDSs for clinical translation and their in vivo safety 
      assessment are discussed.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Sun, Luyao
AU  - Sun L
AD  - Australian Institute for Bioengineering and Nanotechnology, The University of 
      Queensland, Brisbane, QLD 4072, Australia.
FAU - Wang, Jingjing
AU  - Wang J
AD  - Australian Institute for Bioengineering and Nanotechnology, The University of 
      Queensland, Brisbane, QLD 4072, Australia.
FAU - Li, Li
AU  - Li L
AD  - Australian Institute for Bioengineering and Nanotechnology, The University of 
      Queensland, Brisbane, QLD 4072, Australia. Electronic address: l.li2@uq.edu.au.
FAU - Xu, Zhi Ping
AU  - Xu ZP
AD  - Australian Institute for Bioengineering and Nanotechnology, The University of 
      Queensland, Brisbane, QLD 4072, Australia. Electronic address: 
      gordonxu@uq.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211101
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Inorganic Chemicals)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Drug Evaluation, Preclinical
MH  - Humans
MH  - *Inorganic Chemicals
MH  - Molecular Structure
MH  - *Nanostructures
OTO - NOTNLM
OT  - Disassembly and reassembly
OT  - Dynamic drug delivery systems
OT  - Stimuli-driven theranostic
OT  - Surface functionalization
OT  - Transformable 2D inorganic nanomaterials
OT  - Tumor microenvironment
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/11/06 06:00
MHDA- 2022/03/19 06:00
CRDT- 2021/11/05 05:48
PHST- 2021/04/06 00:00 [received]
PHST- 2021/10/07 00:00 [revised]
PHST- 2021/10/27 00:00 [accepted]
PHST- 2021/11/06 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/11/05 05:48 [entrez]
AID - S0169-409X(21)00424-5 [pii]
AID - 10.1016/j.addr.2021.114031 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2022 Jan;180:114031. doi: 10.1016/j.addr.2021.114031. Epub 
      2021 Nov 1.