PMID- 34737592
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - Cognitive Impairment and Related Factors Among Middle-Aged and Elderly Patients 
      with Type 2 Diabetes from a Bio-Psycho-Social Perspective.
PG  - 4361-4369
LID - 10.2147/DMSO.S333373 [doi]
AB  - OBJECTIVE: This study investigated the biomedical, psychological, and social 
      behavior risk factors for cognitive impairment in middle-aged and elderly 
      patients with type 2 diabetes mellitus (T2DM). METHODS: This cross-sectional 
      study included 240 patients with T2DM. A questionnaire was used to collect 
      demographic and disease-related data on patients, and the Self-rating Depression 
      Scale (SDS), Diabetes Self-care Scale (DSCS), and Social Support Rating Scale 
      (SSRS) were used to assess patients' depression status, self-management behavior, 
      and social support, respectively. The Chinese version of the Montreal Cognitive 
      Assessment (MoCA) was used to evaluate cognitive function, with a score <26 set 
      as the threshold for cognitive impairment. RESULTS: The prevalence of cognitive 
      dysfunction in middle-aged and elderly patients with T2DM was 52.5%. Multivariate 
      logistic regression analysis showed that older age, a history of hypoglycemia 
      within 1 month, and depression were independent risk factors for cognitive 
      impairment. Education for >12 years, urban living, and a higher total score on 
      the DSCS were independent protective factors against cognitive impairment. 
      CONCLUSION: T2DM patients with high risk of cognitive impairment can be 
      identified early from the bio-psycho-social perspective. Patients with T2DM who 
      are older, less educated, living in rural areas, have hypoglycemia history, and 
      have poor self-management of diabetes are at increased risk of cognitive 
      impairment. Closer monitoring of patients with hypoglycemia, early detection of 
      depression, and improving patients' self-management capacity can prevent 
      cognitive impairment in middle-aged and elderly patients with T2DM.
CI  - (c) 2021 Xu et al.
FAU - Xu, Weiran
AU  - Xu W
AUID- ORCID: 0000-0001-8837-2914
AD  - School of Nursing, Sun Yat-sen University, Guangzhou, People's Republic of China.
FAU - Hu, Xiling
AU  - Hu X
AUID- ORCID: 0000-0001-7888-2267
AD  - Department of Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, People's Republic of China.
FAU - Zhang, Xing
AU  - Zhang X
AD  - Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital of Sun 
      Yat-sen University, Zhuhai, People's Republic of China.
FAU - Ling, Cong
AU  - Ling C
AD  - Department of Neurosurgery, The Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Wang, Chaofan
AU  - Wang C
AD  - Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, People's Republic of China.
FAU - Gao, Lingling
AU  - Gao L
AUID- ORCID: 0000-0002-0159-4344
AD  - School of Nursing, Sun Yat-sen University, Guangzhou, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20211028
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8560081
OTO - NOTNLM
OT  - cognitive impairment
OT  - depression
OT  - self-care
OT  - social support
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/11/06 06:00
MHDA- 2021/11/06 06:01
PMCR- 2021/10/28
CRDT- 2021/11/05 06:46
PHST- 2021/08/14 00:00 [received]
PHST- 2021/10/15 00:00 [accepted]
PHST- 2021/11/05 06:46 [entrez]
PHST- 2021/11/06 06:00 [pubmed]
PHST- 2021/11/06 06:01 [medline]
PHST- 2021/10/28 00:00 [pmc-release]
AID - 333373 [pii]
AID - 10.2147/DMSO.S333373 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Oct 28;14:4361-4369. doi: 10.2147/DMSO.S333373. 
      eCollection 2021.