PMID- 34738190
OWN - NLM
STAT- MEDLINE
DCOM- 20221107
LR  - 20221107
IS  - 1941-6636 (Electronic)
VI  - 53
IP  - 4
DP  - 2022 Dec
TI  - Overexpression of lncRNA DLEU1 in Gastric Cancer Tissues Compared to Adjacent 
      Non-Tumor Tissues.
PG  - 990-994
LID - 10.1007/s12029-021-00733-8 [doi]
AB  - PURPOSE: Gastric cancer (GC) is caused by environmental factors and genetic 
      changes of protein-coding- and non-coding sequences, which entail short 
      non-coding RNAs (microRNAs) and long non-coding RNAs (lncRNAs). DLEU1 (deleted in 
      lymphocytic leukemia 1), as an effective lncRNA located on chromosome 14.3q 13, 
      modulates the nuclear factor-kB (NF-kB) signaling pathway. This gene usually 
      plays an oncogenic role in the tumorigenesis of multiple types of cancer. The 
      present study examined the expression level of DLEU1 and its association with 
      clinical-pathological characteristics in GC. METHODS: Total RNA of 100 specimens 
      was extracted by TRIzol reagent. After cDNA synthesis, qRT-PCR analysis was 
      performed to measure the expression level of the DLEU1 gene and the obtained data 
      were analyzed by SPSS 16.0. RESULTS: The relative expression level of DLEU1 
      significantly increased in tumor specimens compared to the normal tumor margin 
      specimens. The biomarker index of lncRNA DLEU1 was 0.7 in tumor tissues. The 
      observed high expression level of DLEU1 was pertinent to the pathological 
      progressive TNM stage, lymph node metastasis, differentiation degree, patient's 
      age and lifestyle, and Helicobacter pylori infection in GC patients. CONCLUSION: 
      The obtained findings suggested that DLEU1 acts as an oncogene in GC and might be 
      a new target for gene therapy of GC.
CI  - (c) 2021. Springer Science+Business Media, LLC, part of Springer Nature.
FAU - Ghodrati, Roghieh
AU  - Ghodrati R
AD  - Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, 
      Tabriz, Iran.
FAU - Safaralizadeh, Reza
AU  - Safaralizadeh R
AUID- ORCID: 0000-0002-6970-6998
AD  - Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, 
      Tabriz, Iran. Safaralizadeh@tabrizu.ac.ir.
FAU - Dastmalchi, Narges
AU  - Dastmalchi N
AD  - Department of Biology, University College of Nabi Akram, Tabriz, Iran.
FAU - Hosseinpourfeizi, Mohammadali
AU  - Hosseinpourfeizi M
AD  - Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, 
      Tabriz, Iran.
FAU - Asadi, Milad
AU  - Asadi M
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Shirmohammadi, Masoud
AU  - Shirmohammadi M
AD  - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Baradaran, Behzad
AU  - Baradaran B
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20211105
PL  - United States
TA  - J Gastrointest Cancer
JT  - Journal of gastrointestinal cancer
JID - 101479627
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (DLEU1 lncRNA, human)
SB  - IM
MH  - Humans
MH  - Carcinogenesis/genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Helicobacter Infections/genetics
MH  - *RNA, Long Noncoding/genetics
MH  - *Stomach Neoplasms/genetics
MH  - Tumor Suppressor Proteins/genetics
OTO - NOTNLM
OT  - DLEU1 gene
OT  - Gastric cancer
OT  - Long non-coding RNAs
EDAT- 2021/11/06 06:00
MHDA- 2022/11/05 06:00
CRDT- 2021/11/05 06:55
PHST- 2021/10/06 00:00 [accepted]
PHST- 2021/11/06 06:00 [pubmed]
PHST- 2022/11/05 06:00 [medline]
PHST- 2021/11/05 06:55 [entrez]
AID - 10.1007/s12029-021-00733-8 [pii]
AID - 10.1007/s12029-021-00733-8 [doi]
PST - ppublish
SO  - J Gastrointest Cancer. 2022 Dec;53(4):990-994. doi: 10.1007/s12029-021-00733-8. 
      Epub 2021 Nov 5.