PMID- 34739390
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 10
IP  - 12
DP  - 2021 Nov 29
TI  - Angiopoietin-like proteins 3, 4 and 8 are linked to cardiovascular function in 
      naive sub-clinical and overt hypothyroid patients receiving levothyroxine 
      therapy.
PG  - 1570-1583
LID - 10.1530/EC-21-0398 [doi]
AB  - OBJECTIVE: Angiopoietin-like proteins (ANGPTL) 3, 4 and 8 are upcoming 
      cardiovascular biomarkers. Experimental studies showed that thyroid hormones 
      altered their levels. We assessed ANGPTL3, 4 and 8 as predictors of 
      cardiovascular functions among naive subclinical and naive overt hypothyroidism 
      (SCH and OH) and altered ANGPTL levels with levothyroxine replacement (LT4) and 
      their association with improved cardiovascular risk factors and cardiovascular 
      function. DESIGN AND METHODS: The study was a prospective follow-up study that 
      assessed ANGPTL3, 4 and 8 levels, vascular status (flow-mediated dilation% of 
      brachial artery (FMD%), carotid intima-media thickness (CIMT), aortic stiffness 
      index (ASI)), left ventricle (LV) parameters (ejection fraction (EF), myocardial 
      performance index (MPI), and LV mass), well-known cardiovascular risk factors and 
      homeostatic model for the assessment of insulin resistance, at two time points, 
      that is, among naive SCH, naive OH, and healthy subjects groups; and at 6 months 
      after achieving the euthyroid state with LT4 by calculating their increased or 
      decreased delta changes (∆ upward arrow or ∆ downward arrow) in longitudinal arm among LT4-hypothyroid 
      groups. RESULTS: Significantly elevated levels of ANGPTL3, 4 and 8 among 
      hypothyroid groups than the healthy subjects were reduced with LT4. Multivariate 
      analysis revealed ANGPTLs as independent predictors of cardiovascular functions 
      and the contributors for ANGPTL level included ANGPTL3 and 4 for impaired FMD%, 
      and ANGPTL8 for LV mass among naive SCH; ANGPTL3 for EF% and ANGPTL8 for CIMT in 
      naive OH; ∆ downward arrowANGPTL3 for ∆ downward arrowASI meanwhile ∆ upward arrowfreeT4 for ∆ downward arrowANGPTL3, ∆ downward arrowfasting 
      glucose, ∆ downward arrowtriglyceride, and ∆ downward arrowthyroid peroxidase antibody for ∆ downward arrowANGPTL4 among 
      LT4-SCH. ∆ downward arrowANGPTL4 for ∆ downward arrowMPI and ∆ downward arrowLV mass, meanwhile ∆ downward arrowTSH and ∆ downward arrowtriglyceride 
      for ∆ downward arrowANGPTL3, ∆ upward arrowfree T3 and ∆ downward arrowHOMA-IR for ∆ downward arrowANGPTL4, and systolic blood pressure 
      and waist circumference for ∆ downward arrowANGPTL8 among LT4-OH. CONCLUSION: Elevated ANGPTL3, 
      4 and 8 levels are differentially independent predictors of endothelial and 
      cardiac function and are reduced with LT4 in SCH and OH.
FAU - El Hini, Sahar Hossam
AU  - El Hini SH
AD  - Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of 
      Medicine, Minia University, Minia, Egypt.
FAU - Mahmoud, Yehia Zakaria
AU  - Mahmoud YZ
AD  - Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, 
      Egypt.
FAU - Saedii, Ahmed Abdelfadel
AU  - Saedii AA
AD  - Department of Clinical Pathology, Faculty of Medicine, Minia University, Minia, 
      Egypt.
FAU - Mahmoud, Sayed Shehata
AU  - Mahmoud SS
AD  - Department of Cardiology, Faculty of Medicine, Minia University, Minia, Egypt.
FAU - Amin, Mohamed Ahmed
AU  - Amin MA
AUID- ORCID: 0000-0003-2854-7553
AD  - Department of Radiology, Faculty of Medicine, Minia University, Minia, Egypt.
FAU - Mahmoud, Shereen Riad
AU  - Mahmoud SR
AD  - Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of 
      Medicine, Minia University, Minia, Egypt.
FAU - Matta, Ragaa Abdelshaheed
AU  - Matta RA
AUID- ORCID: 0000-0002-3516-2566
AD  - Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of 
      Medicine, Minia University, Minia, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20211129
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC8679937
OTO - NOTNLM
OT  - ANGPTL3
OT  - ANGPTL4
OT  - ANGPTL8
OT  - endothelial and cardiac function
OT  - subclinical and overt hypothyroidism
EDAT- 2021/11/06 06:00
MHDA- 2021/11/06 06:01
PMCR- 2021/11/05
CRDT- 2021/11/05 17:16
PHST- 2021/10/01 00:00 [received]
PHST- 2021/11/05 00:00 [accepted]
PHST- 2021/11/06 06:00 [pubmed]
PHST- 2021/11/06 06:01 [medline]
PHST- 2021/11/05 17:16 [entrez]
PHST- 2021/11/05 00:00 [pmc-release]
AID - EC-21-0398.R1 [pii]
AID - EC-21-0398 [pii]
AID - 10.1530/EC-21-0398 [doi]
PST - epublish
SO  - Endocr Connect. 2021 Nov 29;10(12):1570-1583. doi: 10.1530/EC-21-0398.