PMID- 34740041
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 132
IP  - 12
DP  - 2021 Dec
TI  - Somatosensory inputs modulate the excitability of cerebellar-cortical 
      interaction.
PG  - 3095-3103
LID - S1388-2457(21)00758-6 [pii]
LID - 10.1016/j.clinph.2021.08.026 [doi]
AB  - OBJECTIVE: Transcranial magnetic stimulation (TMS) delivered over the cerebellum 
      5-7 ms prior to a stimulus over the contralateral primary motor cortex (M1) 
      reduces the excitability of M1 output, a phenomenon termed cerebellar brain 
      inhibition (CBI). The cerebellum receives sensory information for adaptive motor 
      coordination and motor planning. Here, we explored through TMS whether a 
      peripheral electrical stimulus modulates CBI. METHODS: We studied the effect of 
      right median nerve electrical stimulation (ES) on CBI from right cerebellum 
      (conditioning stimulus, CS) to left M1 (test stimulus, TS) in 12 healthy 
      subjects. The following ES-CS inter-stimulus intervals (ISIs) were tested: 25, 30 
      and 35 ms. CS-TS ISI was set at 5 ms. RESULTS: We found significantly weaker CBI 
      when the ES was delivered 25 ms (p < 0.001) and 35 ms (p < 0.001) earlier the CS 
      over the ipsilateral cerebellum and a trend for 30 ms ES-CS ISI (p = 0.07). 
      CONCLUSIONS: We hypothesize that the activation of cerebellar interneurons 
      together with intrinsic properties of Purkinje cells may be responsible of the 
      decreased CBI when the peripheral stimulation preceded the cerebellar stimulation 
      of 25 and 35 ms. SIGNIFICANCE: To test the interaction between somatosensory 
      inputs and cerebello-cortical pathway may be important in a variety of motor 
      tasks and neuropsychiatric disorders.
CI  - Copyright (c) 2021 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Bonassi, Gaia
AU  - Bonassi G
AD  - S.C. Medicina Fisica e Riabilitazione Ospedaliera, ASL4, Azienda Sanitaria 
      Locale, Chiavarese, Italy.
FAU - Pelosin, Elisa
AU  - Pelosin E
AD  - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and 
      Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy; IRCCS, Ospedale 
      Policlinico San Martino, 16132 Genoa, Italy.
FAU - Lagravinese, Giovanna
AU  - Lagravinese G
AD  - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and 
      Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy; IRCCS, Ospedale 
      Policlinico San Martino, 16132 Genoa, Italy.
FAU - Bisio, Ambra
AU  - Bisio A
AD  - Department of Experimental Medicine (DIMES), Section of Human Physiology, 
      University of Genoa, 16132 Genoa, Italy.
FAU - Grasselli, Giorgio
AU  - Grasselli G
AD  - IRCCS, Ospedale Policlinico San Martino, 16132 Genoa, Italy; Istituto Italiano di 
      Tecnologia, Center for Synaptic Neuroscience and Technology, 16132 Genoa, Italy.
FAU - Bove, Marco
AU  - Bove M
AD  - IRCCS, Ospedale Policlinico San Martino, 16132 Genoa, Italy; Department of 
      Experimental Medicine (DIMES), Section of Human Physiology, University of Genoa, 
      16132 Genoa, Italy.
FAU - Avanzino, Laura
AU  - Avanzino L
AD  - IRCCS, Ospedale Policlinico San Martino, 16132 Genoa, Italy; Department of 
      Experimental Medicine (DIMES), Section of Human Physiology, University of Genoa, 
      16132 Genoa, Italy. Electronic address: lavanzino76@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211018
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Cerebellum/*physiology
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/physiology
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Neural Pathways/physiology
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - Cerebellar brain inhibition
OT  - Cerebellum
OT  - Motor learning
OT  - Peripheral stimulation
OT  - Transcranial magnetic stimulation
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/11/06 06:00
MHDA- 2021/12/21 06:00
CRDT- 2021/11/05 20:16
PHST- 2021/05/17 00:00 [received]
PHST- 2021/08/02 00:00 [revised]
PHST- 2021/08/29 00:00 [accepted]
PHST- 2021/11/06 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/11/05 20:16 [entrez]
AID - S1388-2457(21)00758-6 [pii]
AID - 10.1016/j.clinph.2021.08.026 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2021 Dec;132(12):3095-3103. doi: 10.1016/j.clinph.2021.08.026. 
      Epub 2021 Oct 18.