PMID- 34741231
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20220114
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 66
IP  - 1
DP  - 2022 Jan
TI  - Acquired night blindness due to rod dysfunction after long-term hemodialysis.
PG  - 1-7
LID - 10.1007/s10384-021-00883-z [doi]
AB  - PURPOSE: To report the clinical findings in 6 patients who developed night 
      blindness after long-term hemodialysis. STUDY DESIGN: Retrospective case series. 
      PATIENTS AND METHODS: The medical charts of the 6 patients were examined. The 
      fundus photographs, spectral-domain optical coherence tomographic (SD-OCT) 
      images, full-field ERGs, and blood chemistry panels were analyzed. RESULTS: The 
      mean age of the 6 patients (4 men) at the time of diagnosis was 69.1 +/- 5.9 years. 
      The mean duration of the hemodialysis was 21.8 +/- 13.4 years (7-41 years). The 
      visual acuity of the patients was preserved at 20/30 or better except in 1 eye. 
      Ophthalmoscopy showed white flecks that were scattered over the midperipheral 
      retina in all the eyes. SD-OCT showed mild macular degeneration in 5 eyes. The 
      scotopic ERGs elicited by dim flashes were absent, and those elicited by bright 
      flashes had negative waveforms. The photopic ERGs were relatively well preserved. 
      These data indicated a rod-specific dysfunction that may account for the night 
      blindness. The plasma concentration of vitamin A was within the normal range in 4 
      of the patients and slightly lower than the normal limit in 1 of the patients. 
      Administration of vitamin A was performed for 1 patient, and the symptom of night 
      blindness and scotopic ERGs were improved 3 months later. DISCUSSION: Long-term 
      hemodialysis can be associated with the night blindness that may be caused by 
      vitamin A deficiency, even though the plasma concentration of vitamin A in these 
      patients was within the normal range.
CI  - (c) 2021. Japanese Ophthalmological Society.
FAU - Ueno, Shinji
AU  - Ueno S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan. ueno@med.nagoya-u.ac.jp.
FAU - Okado, Satoshi
AU  - Okado S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 
      Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
LA  - eng
GR  - 19K09928/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20211106
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
SB  - IM
MH  - Aged
MH  - Electroretinography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Night Blindness/diagnosis/etiology
MH  - Renal Dialysis/adverse effects
MH  - Retina
MH  - Retrospective Studies
OTO - NOTNLM
OT  - ERGs
OT  - Hemodialysis
OT  - Night blindness
OT  - Rod dysfunction
OT  - Vitamin A deficiency
EDAT- 2021/11/07 06:00
MHDA- 2022/01/15 06:00
CRDT- 2021/11/06 06:13
PHST- 2021/04/20 00:00 [received]
PHST- 2021/09/17 00:00 [accepted]
PHST- 2021/11/07 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2021/11/06 06:13 [entrez]
AID - 10.1007/s10384-021-00883-z [pii]
AID - 10.1007/s10384-021-00883-z [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2022 Jan;66(1):1-7. doi: 10.1007/s10384-021-00883-z. Epub 2021 
      Nov 6.