PMID- 34741792
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Feb
TI  - A Biomimetic Nonantibiotic Nanoplatform for Low-Temperature Photothermal 
      Treatment of Urinary Tract Infections Caused by Uropathogenic Escherichia coli.
PG  - e2101633
LID - 10.1002/adhm.202101633 [doi]
AB  - Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) 
      remain a matter of concern, as the clinical use of multiple antibiotics induces 
      antibiotic resistance in bacteria, resulting in the failure of treatments. 
      Despite the emergence of anti-adhesion strategies that can prevent the 
      development of bacterial drug resistance, these strategies are mainly used for 
      disease prevention rather than effective treatment. Photothermal therapy (PTT) 
      has emerged as an efficient alternative for the elimination of bacteria. 
      Nevertheless, high local temperatures related to PTT probably cause damage to 
      surrounding healthy tissue. Herein, a biomimetic nonantibiotic nanoplatform for 
      low-temperature photothermal treatment of UTIs is developed. The nanoplatform 
      comprises polydopamine (PDA) photothermal core and biphenyl mannoside (Man) shell 
      with multivalent high-affinity to UPEC. Scanning electron microscope (SEM) shows 
      PDA-Man possessed ultra-strong targeting binding ability toward UPEC. It is the 
      fact that this impulse UPEC to form a large bacterial cluster. Consequently, the 
      high photothermal energy of the PDA-Man appears predominantly in the affected 
      bacterial area, while the overall environment remains at a low temperature. The 
      fabricated nanoplatform shows excellent photothermal bactericidal effects, 
      approximately 100% in a UTI model. Overall, this low-temperature photothermal 
      nanoplatform provides an appropriate strategy for the elimination of bacteria in 
      clinical applications.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Wenjie, Shi
AU  - Wenjie S
AD  - School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Drug 
      Targeting and Bioimaging, Tianjin Enterprise Key Laboratory for Application 
      Research of Hyaluronic Acid, Tianjin Key Laboratory of Organic Solar Cells and 
      Photochemical Conversion, Tianjin University of Technology, Tianjin, 300384, P. 
      R. China.
FAU - Jinxia, An
AU  - Jinxia A
AD  - School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Drug 
      Targeting and Bioimaging, Tianjin Enterprise Key Laboratory for Application 
      Research of Hyaluronic Acid, Tianjin Key Laboratory of Organic Solar Cells and 
      Photochemical Conversion, Tianjin University of Technology, Tianjin, 300384, P. 
      R. China.
FAU - He, Tan
AU  - He T
AD  - School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Drug 
      Targeting and Bioimaging, Tianjin Enterprise Key Laboratory for Application 
      Research of Hyaluronic Acid, Tianjin Key Laboratory of Organic Solar Cells and 
      Photochemical Conversion, Tianjin University of Technology, Tianjin, 300384, P. 
      R. China.
FAU - Mengran, Jia
AU  - Mengran J
AD  - School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Drug 
      Targeting and Bioimaging, Tianjin Enterprise Key Laboratory for Application 
      Research of Hyaluronic Acid, Tianjin Key Laboratory of Organic Solar Cells and 
      Photochemical Conversion, Tianjin University of Technology, Tianjin, 300384, P. 
      R. China.
FAU - Hui, Gao
AU  - Hui G
AUID- ORCID: 0000-0002-5009-9999
AD  - State Key Laboratory of Separation Membranes and Membrane Processes, School of 
      Materials Science and Engineering, Tiangong University, Tianjin, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220107
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology/therapeutic use
MH  - Biomimetics
MH  - *Escherichia coli Infections/drug therapy
MH  - Humans
MH  - Temperature
MH  - *Urinary Tract Infections/drug therapy/microbiology
MH  - *Uropathogenic Escherichia coli/metabolism
OTO - NOTNLM
OT  - low-temperature photothermal therapy
OT  - mannoside
OT  - polydopamine nanoparticles
OT  - urinary tract infections
OT  - uropathogenic Escherichia coli
EDAT- 2021/11/07 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/11/06 17:14
PHST- 2021/10/30 00:00 [revised]
PHST- 2021/08/09 00:00 [received]
PHST- 2021/11/07 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/11/06 17:14 [entrez]
AID - 10.1002/adhm.202101633 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2022 Feb;11(3):e2101633. doi: 10.1002/adhm.202101633. Epub 
      2022 Jan 7.