PMID- 34742449
OWN - NLM
STAT- MEDLINE
DCOM- 20220211
LR  - 20220211
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 275
DP  - 2022 Jan 1
TI  - Chitosan-based DDSs for pH/hypoxia dual-triggered DOX delivery: Facile morphology 
      modulation for higher in vitro cytotoxicity.
PG  - 118760
LID - S0144-8617(21)01147-4 [pii]
LID - 10.1016/j.carbpol.2021.118760 [doi]
AB  - The morphology of the drug delivery systems (DDSs) has been recognized to play an 
      important role in their phagocytosis, cellular interaction and distribution. 
      However, it is a technical challenge to simply prepare the non-spherical 
      nanoscaled DDSs. Here, a facile strategy was developed to fabricate the 
      pH/hypoxia dual-responsive nanowires by adding the maleic acid (MAH) and PEG 
      modified chitosan (PEG-SS-CS-MAH) into aqueous solution of DOX. Compared with the 
      PEG-SS-CS-MAH/DOX nanoparticles (NPs) by adding DOX into the PEG-SS-CS-MAH 
      solution, the PEG-SS-CS-MAH/DOX nanowires (NWs) possessed a higher drug loading 
      capacity of 58% and better pH/hypoxia dual-triggered DOX release performance with 
      higher drug release in the simulated tumor intracellular microenvironment but a 
      much lower premature drug leakage in the simulated normal physiological medium. 
      As a result, higher in vitro anti-tumor efficacy was achieved with the 
      PEG-SS-CS-MAH/DOX NWs, demonstrating their promising potential for tumor 
      chemotherapy.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Xie, Pengwei
AU  - Xie P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic 
      address: pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211016
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Drug Carriers)
RN  - 80168379AG (Doxorubicin)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Antibiotics, Antineoplastic/administration & dosage/chemistry/*pharmacology
MH  - Cell Hypoxia/*drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Chitosan/administration & dosage/*chemistry
MH  - Doxorubicin/administration & dosage/chemistry/*pharmacology
MH  - Drug Carriers/administration & dosage/chemistry
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Drug Screening Assays, Antitumor
MH  - Flow Cytometry
MH  - Hep G2 Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Molecular Structure
MH  - Nanoparticles/chemistry
MH  - Particle Size
OTO - NOTNLM
OT  - Chitosan
OT  - Drug delivery system
OT  - Morphology
OT  - Nanowires
OT  - Tumor chemotherapy
EDAT- 2021/11/08 06:00
MHDA- 2022/02/12 06:00
CRDT- 2021/11/07 20:24
PHST- 2021/08/08 00:00 [received]
PHST- 2021/09/26 00:00 [revised]
PHST- 2021/10/09 00:00 [accepted]
PHST- 2021/11/07 20:24 [entrez]
PHST- 2021/11/08 06:00 [pubmed]
PHST- 2022/02/12 06:00 [medline]
AID - S0144-8617(21)01147-4 [pii]
AID - 10.1016/j.carbpol.2021.118760 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2022 Jan 1;275:118760. doi: 10.1016/j.carbpol.2021.118760. Epub 
      2021 Oct 16.