PMID- 34745278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231221
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2021
DP  - 2021
TI  - Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of 
      Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee 
      Osteoarthritis.
PG  - 3210494
LID - 10.1155/2021/3210494 [doi]
LID - 3210494
AB  - Knee osteoarthritis (KOA) has become one of the leading causes of workforce loss 
      in the middle-aged and elderly population and a global public health problem 
      second only to cardiovascular disease, so we need to find more effective 
      treatments for this disease. In this study, we selected 120 patients with KOA 
      admitted to our hospital from June 2018 to December 2020 and divided them into 
      treatment group 1, treatment group 2, and joint group according to the random 
      number table method, with 40 patients in each group. Treatment group 1 was 
      treated with Tongluozhitong prescription dip-soaking therapy, treatment 2 group 
      was treated with intra-articular injection of sodium hyaluronate, and the joint 
      group was treated with a combination of both modalities for 4 weeks in all three 
      groups. Clinical efficacy, visual analogue scale (VAS), Lysholm knee score (LKS), 
      activity of daily living score (ADL), the levels of bone metabolic markers such 
      as cartilage oligomeric matrix protein (COMP), type II collagen degradation maker 
      (CTX-II), and matrix metalloproteinase-3 (MMP-3), and the levels of inflammatory 
      mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and 
      hypersensitive C-reactive protein (hs-CRP) were used as observations to compare 
      and analyze the therapeutic effects of the three treatment regimens in KOA 
      patients. The results showed that the clinical excellence rates of the joint 
      group, treatment group 1, and treatment group 2 were 72.50%, 50.00%, and 90.00%, 
      respectively, with statistically significant differences between any two 
      comparisons. After treatment, VAS scores, serum COMP, CTX-II, MMP-3, IL-1beta, 
      TNF-alpha, and hs-CRP levels decreased in all three groups, and the levels of each 
      index were as follows: joint group < treatment group 1 < treatment group 2, and 
      the difference between any two comparisons was statistically significant. The LKS 
      score and ADL score increased in all three groups, and the levels of each index 
      were as follows: joint group > treatment group 1 > treatment group 2, with 
      statistically significant differences in any two groups compared. None of the 
      patients in the three groups experienced any significant adverse effects during 
      treatment. This suggests that the dip-soaking therapy of Tongluozhitong 
      prescription is more advantageous than intra-articular sodium hyaluronate 
      injection treatment in suppressing the level of serum bone metabolic markers and 
      inflammatory mediators, reducing pathological joint damage, relieving symptoms of 
      pain, alleviating degenerative joint symptoms, and improving knee function in KOA 
      patients. The combination of the two in KOA patients can significantly improve 
      the efficacy and has a good safety profile.
CI  - Copyright (c) 2021 Jianfang Gong et al.
FAU - Gong, Jianfang
AU  - Gong J
AUID- ORCID: 0000-0002-0912-2907
AD  - Department of Traditional Chinese Medicine, Bethune Hospital, Taiyuan, Shanxi 
      030032, China.
FAU - Li, Qiang
AU  - Li Q
AD  - Department of Orthopaedics, Bethune Hospital, Taiyuan, Shanxi 030032, China.
FAU - Wei, Mengling
AU  - Wei M
AD  - Department of Traditional Chinese Medicine, Bethune Hospital, Taiyuan, Shanxi 
      030032, China.
FAU - Xue, Liangliang
AU  - Xue L
AD  - Department of Radiology, Bethune Hospital, Taiyuan, Shanxi 030032, China.
FAU - Liu, Yinlian
AU  - Liu Y
AD  - Department of Rehabilitation, Bethune Hospital, Taiyuan, Shanxi 030032, China.
FAU - Gao, Jun
AU  - Gao J
AD  - Department of Traditional Chinese Medicine, Bethune Hospital, Taiyuan, Shanxi 
      030032, China.
FAU - Qin, Tiantian
AU  - Qin T
AD  - Department of Traditional Chinese Medicine, Bethune Hospital, Taiyuan, Shanxi 
      030032, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20211028
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
RIN - Evid Based Complement Alternat Med. 2023 Dec 13;2023:9835432. PMID: 38125171
PMC - PMC8568548
COIS- The authors declare no conflicts of interest, financial or otherwise.
EDAT- 2021/11/09 06:00
MHDA- 2021/11/09 06:01
PMCR- 2021/10/28
CRDT- 2021/11/08 06:38
PHST- 2021/09/08 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/11/08 06:38 [entrez]
PHST- 2021/11/09 06:00 [pubmed]
PHST- 2021/11/09 06:01 [medline]
PHST- 2021/10/28 00:00 [pmc-release]
AID - 10.1155/2021/3210494 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2021 Oct 28;2021:3210494. doi: 
      10.1155/2021/3210494. eCollection 2021.