PMID- 34745434
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231108
IS  - 1976-8354 (Print)
IS  - 2151-2485 (Electronic)
IS  - 1976-8354 (Linking)
VI  - 25
IP  - 5
DP  - 2021
TI  - Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic 
      dermatitis-like phenotypes in BALB/c mice.
PG  - 272-282
LID - 10.1080/19768354.2021.1974938 [doi]
AB  - Zea mays L. (Poaceae), also known as purple corn, is an annual herbaceous plant 
      that is grown as food for human consumption in a variety of forms, including 
      cooking oils and sweeteners in processed food and beverage products. The purpose 
      of this study was to determine whether a novel purple corn extract, FB801, might 
      have an anti-atopic dermatitis (AD) effect on AD-like skin lesions induced by 
      2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. Topical sensitization (1%) and 
      challenge (0.3%) by DNCB were performed on the dorsal skin and right ear of 
      BALB/c mice to induce AD. Following FB801 and dexamethasone administered orally, 
      the severity of skin lesions was examined macroscopically and histologically. 
      Serum levels of immunoglobulin E (IgE) and various cytokines were determined by 
      enzyme-linked immunosorbent assay. Oral administration of FB801 significantly 
      reduced typical symptoms of AD (erythema/bleeding, swelling, molting/erosion and 
      scaling/drying), scratching frequencies, and the recruitment of inflammatory and 
      mast cells. In addition, FB801 suppressed serum levels of IgE and T helper (Th)2 
      type cytokines such as interleukin (IL)-4 and IL-10 in DNCB-treated BALB/c mice. 
      Furthermore, FB801 reduced the degradation of inhibitor of nuclear factor-kappaB 
      proteins (NF-kappaB) in tumor necrosis factor (TNF)-alpha-stimulated human keratinocyte 
      (HaCaT) cells. These results suggest that FB801 inhibited the development of the 
      AD-like skin symptoms by regulating Th1 and Th2 responses in the skin lesions in 
      mice and suppressing TNF-alpha induced NF-kappaB activation in HaCaT cells, suggesting 
      that FB801 has potential application as an effective alternative therapy for the 
      prevention and management of AD.
CI  - (c) 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group.
FAU - No, Huiwon
AU  - No H
AUID- ORCID: 0000-0003-3332-2746
AD  - Department of Biomedical Science, Daegu Catholic University, Gyeongsan-Si, 
      Republic of Korea.
FAU - Nam, Sang Hyun
AU  - Nam SH
AUID- ORCID: 0000-0001-9226-8482
AD  - Department of Biomedical Science, Daegu Catholic University, Gyeongsan-Si, 
      Republic of Korea.
FAU - Seo, Hee Won
AU  - Seo HW
AUID- ORCID: 0000-0002-8019-1382
AD  - Department of Biomedical Science, Daegu Catholic University, Gyeongsan-Si, 
      Republic of Korea.
FAU - Seo, JeongHyeon
AU  - Seo J
AUID- ORCID: 0000-0003-0238-1970
AD  - Department of Biomedical Science, Daegu Catholic University, Gyeongsan-Si, 
      Republic of Korea.
FAU - Park, Soo-Hyun
AU  - Park SH
AUID- ORCID: 0000-0001-7499-5360
AD  - Front Bio Inc., Chuncheon, Republic of Korea.
FAU - Kim, Set-Byeol
AU  - Kim SB
AUID- ORCID: 0000-0002-2806-7077
AD  - Front Bio Inc., Chuncheon, Republic of Korea.
FAU - Jung, Jun-Sub
AU  - Jung JS
AUID- ORCID: 0000-0001-9685-4817
AD  - Front Bio Inc., Chuncheon, Republic of Korea.
FAU - Park, Jongyeol
AU  - Park J
AUID- ORCID: 0000-0003-4743-8192
AD  - Maize Research Institute, Hongcheon-gun, Republic of Korea.
FAU - Choi, Jaekeun
AU  - Choi J
AUID- ORCID: 0000-0002-0242-9092
AD  - Maize Research Institute, Hongcheon-gun, Republic of Korea.
FAU - Lee, Jae-Yong
AU  - Lee JY
AUID- ORCID: 0000-0002-9820-1235
AD  - Front Bio Inc., Chuncheon, Republic of Korea.
AD  - Department of Biochemistry, College of Medicine, Hallym University, Chuncheon, 
      Republic of Korea.
FAU - Suh, Hong-Won
AU  - Suh HW
AUID- ORCID: 0000-0001-8691-6797
AD  - Front Bio Inc., Chuncheon, Republic of Korea.
AD  - Department of Pharmacology, College of Medicine, Hallym University, Chuncheon, 
      Republic of Korea.
FAU - Lim, Soon Sung
AU  - Lim SS
AUID- ORCID: 0000-0002-2488-2090
AD  - Front Bio Inc., Chuncheon, Republic of Korea.
AD  - Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic 
      of Korea.
FAU - Kim, Jin-Kyung
AU  - Kim JK
AUID- ORCID: 0000-0002-2506-4188
AD  - Department of Biomedical Science, Daegu Catholic University, Gyeongsan-Si, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - England
TA  - Anim Cells Syst (Seoul)
JT  - Animal cells and systems
JID - 101478641
PMC - PMC8567911
OTO - NOTNLM
OT  - 2,4-dinitrochlorobenzene
OT  - Atopic dermatitis
OT  - IgE
OT  - purple corn
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2021/11/09 06:00
MHDA- 2021/11/09 06:01
PMCR- 2021/09/08
CRDT- 2021/11/08 06:40
PHST- 2021/11/08 06:40 [entrez]
PHST- 2021/11/09 06:00 [pubmed]
PHST- 2021/11/09 06:01 [medline]
PHST- 2021/09/08 00:00 [pmc-release]
AID - 1974938 [pii]
AID - 10.1080/19768354.2021.1974938 [doi]
PST - epublish
SO  - Anim Cells Syst (Seoul). 2021 Sep 8;25(5):272-282. doi: 
      10.1080/19768354.2021.1974938. eCollection 2021.