PMID- 34749876
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20211110
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 50
IP  - 5
DP  - 2021 Sep
TI  - [Determination of halogenated carboxylic acids in drinking water by ion 
      chromatography-orbitrap mass spectrometry method].
PG  - 805-813
LID - 10.19813/j.cnki.weishengyanjiu.2021.05.017 [doi]
AB  - OBJECTIVE: To establish a method for determination of the common and emerging 
      halogenated carboxylic acids(HCAs) in drinking water by ion chromatography(IC) 
      and quadrupole-orbitrap(Q-Orbitrap) high resolution mass spectrometry(HRMS) 
      combined the traditional quantitative detection with semi-target analysis. 
      METHODS: Effects on the type of chromatographic column, the composition of mobile 
      phase, the flow rate of acetonitrile added post column, the column temperature, 
      and the injection volume were studied in detail for IC-HRMS method, also for HRMS 
      conditions. Drinking water sample was directly injected into IC-HRMS for analysis 
      after filtration. The chromatography separation was performed on an AS21 anion 
      exchange chromatography column(2 mmx250 mm) with the gradient elution using 800 
      mmol/L methylamine-water as mobile phase, and acetonitrile was added after 
      column. The detection was conducted on HRMS with the electrospray ionization 
      negative mode. And the quantitative analysis of 8 haloacetic acids(HAAs) and 
      semi-target screening of 19 HCAs were achieved by full MS/dd-MS~2 mode. RESULTS: 
      Good linearity(r>0.996) was obtained for each of 8 HAAs for IC-HRMS. The 
      method detection limits(MDLs) and method quantification limits(MQLs) were in the 
      range of 0.50-2.5 mug/L and 1.7-8.3 mug/L, respectively. Intra-and inter-day 
      relative standard deviations(RSDs) were in the range of 1.50%-11.0% and 
      4.58%-10.9%, respectively. The recoveries were in the range of 61.3%-117%(n=6). 
      The proposed method was applied to analyze 39 drinking water samples, and 
      dichloroacetic acid and trichloroacetic acid were detected and quantified, with 
      concentrations ranging from 1.35 to 48.0 mug/L. Besides, five HCAs(difluoroacetic 
      acid, trifluoroacetic acid, bromochloroacetic acid, monochloropropionic acid and 
      dichloropropionic acid) were preliminary identified with semi-target screening 
      method. CONCLUSION: The developed method was simple, rapid, no sample preparation 
      except filtration and low reagent cosumption, which could meet the need of 
      drinking water monitoring and achieve comprehensive screening of HCAs in drinking 
      water. In addition, full MS/dd-MS~2 data acquisition mode could provide 
      retrospective analysis of existing data by adding the emerging or interesting 
      HCAs into the screening compound database.
FAU - Luo, Chunying
AU  - Luo C
AD  - Department of Public Health Laboratory Science, West China School of Public 
      Health/West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
FAU - Zhao, Xuan
AU  - Zhao X
AD  - Department of Public Health Laboratory Science, West China School of Public 
      Health/West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
FAU - Luo, Xinyue
AU  - Luo X
AD  - Department of Public Health Laboratory Science, West China School of Public 
      Health/West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
FAU - Yang, Mi
AU  - Yang M
AD  - Department of Public Health Laboratory Science, West China School of Public 
      Health/West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
FAU - Gao, Ge
AU  - Gao G
AD  - Chengdu Center for Disease Control & Prevention, Chengdu 610047, China.
FAU - Xu, Buyi
AU  - Xu B
AD  - Sichuan Provincial Public Security Department, Chengdu 610041, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Public Health Laboratory Science, West China School of Public 
      Health/West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
FAU - Qu, Weidong
AU  - Qu W
AD  - School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Zou, Xiaoli
AU  - Zou X
AD  - Department of Public Health Laboratory Science, West China School of Public 
      Health/West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Carboxylic Acids)
RN  - 0 (Drinking Water)
SB  - IM
MH  - Carboxylic Acids/analysis
MH  - Chromatography, High Pressure Liquid
MH  - *Drinking Water
MH  - Retrospective Studies
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - disinfectant by-products
OT  - drinking water
OT  - halogenated carboxylic acids
OT  - ion chromatography-high resolution mass spectrometry
OT  - quantitative analysis
OT  - semi-target screening
EDAT- 2021/11/10 06:00
MHDA- 2021/11/11 06:00
CRDT- 2021/11/09 05:46
PHST- 2021/11/09 05:46 [entrez]
PHST- 2021/11/10 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
AID - 10.19813/j.cnki.weishengyanjiu.2021.05.017 [doi]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2021 Sep;50(5):805-813. doi: 
      10.19813/j.cnki.weishengyanjiu.2021.05.017.