PMID- 34750522
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20230209
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 91
IP  - 2
DP  - 2022 Jan
TI  - Peripheral immune cells and perinatal brain injury: a double-edged sword?
PG  - 392-403
LID - 10.1038/s41390-021-01818-7 [doi]
AB  - Perinatal brain injury is the leading cause of neurological mortality and 
      morbidity in childhood ranging from motor and cognitive impairment to behavioural 
      and neuropsychiatric disorders. Various noxious stimuli, including perinatal 
      inflammation, chronic and acute hypoxia, hyperoxia, stress and drug exposure 
      contribute to the pathogenesis. Among a variety of pathological phenomena, the 
      unique developing immune system plays an important role in the understanding of 
      mechanisms of injury to the immature brain. Neuroinflammation following a 
      perinatal insult largely contributes to evolution of damage to resident brain 
      cells, but may also be beneficial for repair activities. The present review will 
      focus on the role of peripheral immune cells and discuss processes involved in 
      neuroinflammation under two frequent perinatal conditions, systemic 
      infection/inflammation associated with encephalopathy of prematurity (EoP) and 
      hypoxia/ischaemia in the context of neonatal encephalopathy (NE) and stroke at 
      term. Different immune cell subsets in perinatal brain injury including their 
      infiltration routes will be reviewed and critical aspects such as sex differences 
      and maturational stage will be discussed. Interactions with existing regenerative 
      therapies such as stem cells and also potentials to develop novel 
      immunomodulatory targets are considered. IMPACT: Comprehensive summary of current 
      knowledge on the role of different immune cell subsets in perinatal brain injury 
      including discussion of critical aspects to be considered for development of 
      immunomodulatory therapies.
CI  - (c) 2021. The Author(s).
FAU - Herz, Josephine
AU  - Herz J
AD  - Department of Paediatrics I, Neonatology and Experimental Perinatal 
      Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, 
      Germany. Josephine.herz@uk-essen.de.
AD  - Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of 
      Medicine, University Duisburg-Essen, Essen, Germany. Josephine.herz@uk-essen.de.
FAU - Bendix, Ivo
AU  - Bendix I
AD  - Department of Paediatrics I, Neonatology and Experimental Perinatal 
      Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, 
      Germany.
AD  - Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of 
      Medicine, University Duisburg-Essen, Essen, Germany.
FAU - Felderhoff-Muser, Ursula
AU  - Felderhoff-Muser U
AD  - Department of Paediatrics I, Neonatology and Experimental Perinatal 
      Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, 
      Germany. ursula.felderhoff@uk-essen.de.
AD  - Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of 
      Medicine, University Duisburg-Essen, Essen, Germany. 
      ursula.felderhoff@uk-essen.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211108
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
SB  - IM
MH  - Brain Injuries/*immunology/therapy
MH  - Female
MH  - Humans
MH  - Immunity, Innate
MH  - Leukocytes/classification/immunology
MH  - Lymphocyte Subsets
MH  - Male
PMC - PMC8816729
COIS- The authors declare no competing interests.
EDAT- 2021/11/10 06:00
MHDA- 2022/03/29 06:00
PMCR- 2021/11/08
CRDT- 2021/11/09 06:58
PHST- 2021/06/15 00:00 [received]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/08/24 00:00 [revised]
PHST- 2021/11/10 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/11/09 06:58 [entrez]
PHST- 2021/11/08 00:00 [pmc-release]
AID - 10.1038/s41390-021-01818-7 [pii]
AID - 1818 [pii]
AID - 10.1038/s41390-021-01818-7 [doi]
PST - ppublish
SO  - Pediatr Res. 2022 Jan;91(2):392-403. doi: 10.1038/s41390-021-01818-7. Epub 2021 
      Nov 8.