PMID- 34750725
OWN - NLM
STAT- MEDLINE
DCOM- 20230113
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Print)
IS  - 1071-3581 (Linking)
VI  - 29
IP  - 6
DP  - 2022 Dec
TI  - Pulmonary perfusion and NYHA classification improve after cardiac 
      resynchronization therapy.
PG  - 2974-2983
LID - 10.1007/s12350-021-02848-8 [doi]
AB  - BACKGROUND: Evaluation of cardiac resynchronization therapy (CRT) often includes 
      New York Heart Association (NYHA) classification, and echocardiography. However, 
      these measures have limitations. Perfusion gradients from ventilation/perfusion 
      single-photon emission computed tomography (V/P SPECT) are related to left-heart 
      filling pressures and have been validated against invasive right-heart 
      catheterization. The aim was to assess if changes in perfusion gradients are 
      associated with improvements in heart failure (HF) symptoms after CRT, and if 
      they correlate with currently used diagnostic methods in the follow-up of 
      patients with HF after receiving CRT. METHODS AND RESULTS: Nineteen patients 
      underwent V/P SPECT, echocardiography, NYHA classification, and the 
      quality-of-life scoring system "Minnesota living with HF" (MLWHF), before and 
      after CRT. CRT caused improvement in perfusion gradients from V/P SPECT which 
      were associated with improvements in NYHA classification (P = .0456), whereas 
      improvements in end-systolic volume (LVESV) from echocardiography were not. After 
      receiving CRT, the proportion of patients who improved was lower using LVESV (n = 
      7/19, 37%) than perfusion gradients (n = 13/19, 68%). Neither change in perfusion 
      gradients nor LVESV was associated with changes in MLWHF (P = 1.0, respectively). 
      CONCLUSIONS: Measurement of perfusion gradients from V/P SPECT is a promising 
      quantitative user-independent surrogate measure of left-sided filling pressure in 
      the assessment of CRT response in patients with HF.
CI  - (c) 2021. The Author(s).
FAU - Al-Mashat, Mariam
AU  - Al-Mashat M
AD  - Clinical Physiology, Department of Clinical Sciences Lund, Skane University 
      Hospital, Lund University, Entregatan 7, 22185, Lund, Sweden.
FAU - Borgquist, Rasmus
AU  - Borgquist R
AD  - Cardiology, Arrhythmia Section, Department of Clinical Sciences Lund, Skane 
      University Hospital, Lund University, Lund, Sweden.
FAU - Carlsson, Marcus
AU  - Carlsson M
AD  - Clinical Physiology, Department of Clinical Sciences Lund, Skane University 
      Hospital, Lund University, Entregatan 7, 22185, Lund, Sweden.
FAU - Arheden, Hakan
AU  - Arheden H
AD  - Clinical Physiology, Department of Clinical Sciences Lund, Skane University 
      Hospital, Lund University, Entregatan 7, 22185, Lund, Sweden.
FAU - Jogi, Jonas
AU  - Jogi J
AD  - Clinical Physiology, Department of Clinical Sciences Lund, Skane University 
      Hospital, Lund University, Entregatan 7, 22185, Lund, Sweden. 
      jonas.jogi@med.lu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211108
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
SB  - IM
CIN - J Nucl Cardiol. 2022 Dec;29(6):2984-2987. PMID: 34820772
MH  - Humans
MH  - *Cardiac Resynchronization Therapy
MH  - Treatment Outcome
MH  - Heart
MH  - *Heart Failure/diagnostic imaging/therapy
MH  - Perfusion
PMC - PMC9834347
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - NYHA classification
OT  - echocardiography
OT  - heart failure
OT  - ventilation/perfusion single-photon emission computed tomography
EDAT- 2021/11/10 06:00
MHDA- 2023/01/14 06:00
PMCR- 2021/11/08
CRDT- 2021/11/09 07:05
PHST- 2021/05/03 00:00 [received]
PHST- 2021/10/05 00:00 [accepted]
PHST- 2021/11/10 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
PHST- 2021/11/09 07:05 [entrez]
PHST- 2021/11/08 00:00 [pmc-release]
AID - S1071-3581(23)00668-2 [pii]
AID - 2848 [pii]
AID - 10.1007/s12350-021-02848-8 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2022 Dec;29(6):2974-2983. doi: 10.1007/s12350-021-02848-8. Epub 
      2021 Nov 8.