PMID- 34751249
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2021
DP  - 2021
TI  - S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes.
PG  - 1341750
LID - 10.1155/2021/1341750 [doi]
LID - 1341750
AB  - The pathogenesis of type 2 diabetes mellitus (T2DM) is very complicated. The 
      currently well-accepted etiology is the "Ominous Octet" theory proposed by 
      Professor Defronzo. Since presently used drugs for T2DM have limitations and 
      harmful side effects, studies regarding alternative treatments are being 
      conducted. Analyzing the pharmacological mechanism of biomolecules in view of 
      pathogenesis is an effective way to assess new drugs. Sphingosine 1 phosphate 
      (S1P), an endogenous lipid substance in the human body, has attracted increasing 
      attention in the T2DM research field. This article reviews recent study updates 
      of S1P, summarizing its effects on T2DM with respect to pathogenesis, promoting beta 
      cell proliferation and inhibiting apoptosis, reducing insulin resistance, 
      protecting the liver and pancreas from lipotoxic damage, improving intestinal 
      incretin effects, lowering basal glucagon levels, etc. With increasing research, 
      S1P may help treat and prevent T2DM in the future.
CI  - Copyright (c) 2021 Qiong He et al.
FAU - He, Qiong
AU  - He Q
AUID- ORCID: 0000-0003-2491-8775
AD  - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan 
      030001, Shanxi Province, China.
FAU - Bo, Jiaqi
AU  - Bo J
AUID- ORCID: 0000-0003-2266-0205
AD  - Department of Second Medical College, Shanxi Medical University, Taiyuan 030001, 
      Shanxi Province, China.
FAU - Shen, Ruihua
AU  - Shen R
AUID- ORCID: 0000-0002-6457-5829
AD  - Department of Second Medical College, Shanxi Medical University, Taiyuan 030001, 
      Shanxi Province, China.
FAU - Li, Yan
AU  - Li Y
AUID- ORCID: 0000-0002-0752-1752
AD  - Department of Second Medical College, Shanxi Medical University, Taiyuan 030001, 
      Shanxi Province, China.
FAU - Zhang, Yi
AU  - Zhang Y
AUID- ORCID: 0000-0003-0305-3127
AD  - Department of Pharmacology, Shanxi Medical University, Taiyuan 030001, Shanxi 
      Province, China.
AD  - Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical 
      University, Taiyuan 030001, Shanxi Province, China.
FAU - Zhang, Jiaxin
AU  - Zhang J
AUID- ORCID: 0000-0002-1432-6584
AD  - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan 
      030001, Shanxi Province, China.
FAU - Yang, Jing
AU  - Yang J
AUID- ORCID: 0000-0001-8855-6254
AD  - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan 
      030001, Shanxi Province, China.
FAU - Liu, Yunfeng
AU  - Liu Y
AUID- ORCID: 0000-0003-2826-5804
AD  - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan 
      030001, Shanxi Province, China.
LA  - eng
PT  - Journal Article
DEP - 20210119
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Lysophospholipids)
RN  - 26993-30-6 (sphingosine 1-phosphate)
RN  - NGZ37HRE42 (Sphingosine)
SB  - IM
MH  - Diabetes Mellitus, Type 2/drug therapy/*physiopathology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Liver/drug effects/metabolism/physiopathology
MH  - Lysophospholipids/*metabolism
MH  - Signal Transduction/drug effects/genetics
MH  - Sphingosine/*analogs & derivatives/metabolism
PMC - PMC8571914
COIS- The authors declare no conflicts of interest regarding the publication of this 
      paper.
EDAT- 2021/11/10 06:00
MHDA- 2022/03/29 06:00
PMCR- 2021/01/19
CRDT- 2021/11/09 09:15
PHST- 2020/06/21 00:00 [received]
PHST- 2020/12/24 00:00 [revised]
PHST- 2021/01/04 00:00 [accepted]
PHST- 2021/11/09 09:15 [entrez]
PHST- 2021/11/10 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/01/19 00:00 [pmc-release]
AID - 10.1155/2021/1341750 [doi]
PST - epublish
SO  - J Diabetes Res. 2021 Jan 19;2021:1341750. doi: 10.1155/2021/1341750. eCollection 
      2021.