PMID- 34752688
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20220722
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 69
IP  - 4
DP  - 2022 Jul
TI  - Can presence of HLA type I and II alleles be associated with clinical spectrum of 
      CHIKV infection?
PG  - e895-e905
LID - 10.1111/tbed.14387 [doi]
AB  - Host immune response and virulence factors are key to disease susceptibility. 
      However, there are no known association studies of human leukocyte antigen (HLA) 
      class I and II alleles with chikungunya virus (CHIKV) infection in the Latin 
      American population. Here, we aimed to identify HLA alleles present in patients 
      with CHIKV infection versus healthy controls as well as the allelic association 
      with the clinical spectrum of the disease. We conducted a cross-sectional 
      analysis of a community cohort and included patients aged 18 years and older with 
      serologically confirmed CHIKV infection. HLA typing of HLA-A, HLA-B, and HLA-DRB1 
      alleles was performed. Two-by-two tables were used to establish associations 
      between allele presence and clinical characteristics. Data from 65 patients with 
      confirmed CHIKV infection were analyzed for HLA typing. CHIKV infection was 
      significantly associated with the presence of HLA-A*68 [p = .005; odds ratio 
      (OR): 8.90; 95% confidence interval (CI): 1.88-42.13], HLA-B*35 (p = .03; OR: 
      2.01; 95% CI: 1.06-3.86), HLA-DRB*01 (p <.001; OR: 5.70; 95% CI: 1.95-16.59), 
      HLA-DRB1*04 (p <.001; OR: 7.37; 95% CI: 3.33-16.30), and HLA-DRB1*13 (p = .004; 
      OR: 3.75; 95% CI: 1.50-9.39) alleles in patients versus healthy subjects. A 
      statistically significant relationship was found between the presence of a rash 
      on the face or abdomen and the presence of HLA-DRB1*04 (p = .028; OR: 3.2; 95% 
      CI: 1.11-9.15 and p = .007; OR: 4.33; 95% CI: 1.45-12.88, respectively). Our 
      study demonstrated that, in our cohort, HLA type I and type II alleles are 
      associated with CHIKV infection, and an HLA type II allele is associated with 
      dermatological symptoms. Further research is needed to establish a path for 
      future investigation of genes outside the HLA system to improve knowledge of the 
      pathophysiology of CHIKV infection and its host-pathogen interaction.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Rueda, Juan C
AU  - Rueda JC
AUID- ORCID: 0000-0002-6263-2914
AD  - Student, Biosciences Programme, Faculty of Medicine and Engineering, Universidad 
      de La Sabana, Chia, Colombia.
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
FAU - Santos, Ana M
AU  - Santos AM
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
FAU - Angarita, Jose-Ignacio
AU  - Angarita JI
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
FAU - Saldarriaga, Eugenia-Lucia
AU  - Saldarriaga EL
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
FAU - Pelaez-Ballestas, Ingris
AU  - Pelaez-Ballestas I
AD  - Rheumatology Unit, Hospital General de Mexico "Doctor Eduardo Liceaga", Mexico 
      City, Mexico.
FAU - Espinosa, Alejandro Silva
AU  - Espinosa AS
AD  - Grupo de Genetica Humana, Universidad de La Sabana, Chia, Colombia.
FAU - Briceno-Balcazar, Ignacio
AU  - Briceno-Balcazar I
AD  - Grupo de Genetica Humana, Universidad de La Sabana, Chia, Colombia.
FAU - Arias-Correal, Sofia
AU  - Arias-Correal S
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
FAU - Arias-Correal, Jose
AU  - Arias-Correal J
AUID- ORCID: 0000-0002-3314-4022
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
FAU - Villota-Erazo, Catalina
AU  - Villota-Erazo C
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
AD  - Rheumatology Department, Hospital Militar Central, Bogota, Colombia.
FAU - Reyes, Viviana
AU  - Reyes V
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
AD  - Rheumatology Department, Hospital Militar Central, Bogota, Colombia.
FAU - Bernal-Macias, Santiago
AU  - Bernal-Macias S
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
AD  - Rheumatology Department, Hospital Militar Central, Bogota, Colombia.
FAU - Cardiel, Mario H
AU  - Cardiel MH
AD  - Centro de Investigacion Clinica de Morelia SC, Morelia, Mexico.
FAU - Londono, John
AU  - Londono J
AD  - Grupo de Espondiloartropatias, Rheumatology Department, Universidad de La Sabana, 
      Chia, Colombia.
AD  - Rheumatology Department, Hospital Militar Central, Bogota, Colombia.
LA  - eng
GR  - Colombian Rheumatology Association (ASOREUMA)/
GR  - MED-197-2015/Universidad de La Sabana/
GR  - 757-2016/COLCIENCIAS Doctoral Scholarship/
PT  - Journal Article
DEP - 20211125
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - *Chikungunya Fever/genetics
MH  - Cross-Sectional Studies
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - *HLA-A Antigens/genetics
MH  - *HLA-B Antigens/genetics
MH  - *HLA-DRB1 Chains/genetics
MH  - Humans
OTO - NOTNLM
OT  - Colombia
OT  - HLA
OT  - arbovirus
OT  - chikungunya
OT  - immunogenetics
EDAT- 2021/11/10 06:00
MHDA- 2022/07/22 06:00
CRDT- 2021/11/09 17:39
PHST- 2021/10/18 00:00 [revised]
PHST- 2021/04/30 00:00 [received]
PHST- 2021/10/23 00:00 [accepted]
PHST- 2021/11/10 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2021/11/09 17:39 [entrez]
AID - 10.1111/tbed.14387 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2022 Jul;69(4):e895-e905. doi: 10.1111/tbed.14387. Epub 
      2021 Nov 25.