PMID- 34753299
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 16
IP  - 2
DP  - 2022 Feb
TI  - Integration of low muscle mass into the IPS system and its prognostic 
      significance in patients with Hodgkin's lymphoma.
PG  - 57-67
LID - 10.2217/bmm-2021-0696 [doi]
AB  - Aim: The aim of this study is to determine whether a novel prognostic score can 
      be obtained by including low muscle mass in the international prognostic score 
      (IPS) system. Materials & Methods: Psoas muscle areas were determined in the 
      PET/CT scans of the patients taken for staging at the time of diagnosis and after 
      two cycles of ABVD. After evaluating the effect of low muscle mass on overall 
      survival, receiver operating characteristic (ROC) analyzes were performed by 
      including it in IPS systems. Results: Overall survival was significantly lower in 
      patients with low muscle mass. Adding low muscle mass to IPS scores increased 
      AUC, sensitivity and specificity. Conclusion: The integration of low muscle mass 
      into the IPS scoring systems increased the success of these systems in predicting 
      a prognosis.
FAU - Koyuncu, Mahmut Bakir
AU  - Koyuncu MB
AUID- ORCID: 0000-0002-0507-9294
AD  - Department of Hematology, Adana City Research & Training Hospital, Adana, 01170, 
      Turkey.
FAU - Guler, Erkan
AU  - Guler E
AUID- ORCID: 0000-0003-0881-1003
AD  - Department of General Surgery, Faculty of Medicine, Mersin University, Mersin, 
      33343, Turkey.
FAU - Koseci, Tolga
AU  - Koseci T
AUID- ORCID: 0000-0002-8696-0525
AD  - Department of Medical Oncology, Adana City Research & Training Hospital, Adana, 
      01170, Turkey.
FAU - Ucar, Mehmet Ali
AU  - Ucar MA
AUID- ORCID: 0000-0002-6041-7364
AD  - Department of Hematology, Faculty of Medicine, Cukurova University, Adana, 01260, 
      Turkey.
FAU - Tombak, Anil
AU  - Tombak A
AUID- ORCID: 0000-0002-7195-1845
AD  - Department of Hematology, Faculty of Medicine, Mersin University, Mersin, 33343, 
      Turkey.
FAU - Akdeniz, Aydan
AU  - Akdeniz A
AUID- ORCID: 0000-0002-5160-4803
AD  - Department of Hematology, Faculty of Medicine, Mersin University, Mersin, 33343, 
      Turkey.
FAU - Tiftik, Eyup Naci
AU  - Tiftik EN
AUID- ORCID: 0000-0002-9009-7066
AD  - Department of Hematology, Faculty of Medicine, Mersin University, Mersin, 33343, 
      Turkey.
FAU - Cavusoglu, Cagatay
AU  - Cavusoglu C
AUID- ORCID: 0000-0003-4725-8095
AD  - Department of Geriatrics, Sanliurfa Research & Training Hospital, Sanliurfa, 
      63190, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20211110
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 11056-06-7 (Bleomycin)
RN  - 5V9KLZ54CY (Vinblastine)
RN  - 7GR28W0FJI (Dacarbazine)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols
MH  - Bleomycin/therapeutic use
MH  - Dacarbazine/therapeutic use
MH  - Doxorubicin/therapeutic use
MH  - *Hodgkin Disease/diagnostic imaging
MH  - Humans
MH  - Muscles/pathology
MH  - Neoplasm Staging
MH  - Positron Emission Tomography Computed Tomography
MH  - Prognosis
MH  - Vinblastine/therapeutic use
OAB - Lay abstract Hodgkin's lymphoma is a cancer that responds well to standard 
      treatments. However, the cancer recurs 30% of the time. Improved scoring systems 
      could help better predict the outcomes of treatment. The 'International 
      Prognostic Score' (IPS) system is an algorithm currently used to predict 
      the possibility of death and treatment complications. In this study, low muscle 
      mass is evaluated as data that could be added to the current scoring system to 
      improve the system's ability to predict outcomes. Data from the scans of patients 
      before and after treatment were used to determine the muscle mass. It was found 
      that survival was significantly lower in patients with low muscle mass. This 
      suggests that this information is highly effective in predicting the outcomes of 
      Hodgkin's lymphoma patients.
OABL- eng
OTO - NOTNLM
OT  - Hodgkin's lymphoma
OT  - international prognostic score
OT  - low muscle mass
OT  - psoas muscle index
OT  - sarcopenia
EDAT- 2021/11/11 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/11/10 05:25
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/11/10 05:25 [entrez]
AID - 10.2217/bmm-2021-0696 [doi]
PST - ppublish
SO  - Biomark Med. 2022 Feb;16(2):57-67. doi: 10.2217/bmm-2021-0696. Epub 2021 Nov 10.