PMID- 34754226
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 14
DP  - 2021
TI  - Characteristics of Myocardial Perfusion in Type 2 Diabetes Mellitus and Its 
      Association with Left Ventricular Diastolic Dysfunction: A Study of Myocardial 
      Contrast Echocardiography.
PG  - 7533-7543
LID - 10.2147/IJGM.S340642 [doi]
AB  - BACKGROUND: Diabetic cardiomyopathy (DCM) will gradually progress to heart 
      failure without intervention. The timely identification of left ventricular 
      diastolic dysfunction (LVDD) in the early stage and active intervention helps 
      delay the onset of heart failure. Although myocardial contrast echocardiography 
      (MCE) allows an accurate evaluation of myocardial perfusion (MP), the 
      characteristics of MP in early-stage or even sub-clinical LVDD are still unclear. 
      OBJECTIVE: This study aims to reveal the characteristics of MP in asymptomatic 
      and normotensive patients with type 2 diabetes mellitus (T2DM) using MCE and 
      investigate its association with LVDD development. METHODS: A total of 327 T2DM 
      patients were retrospectively analyzed. Patients diagnosed with LVDD were 
      included in the LVDD+ group (n = 76), and those with normal left ventricular 
      diastolic function were included in the LVDD- group (n = 251). The clinical 
      characteristics, general echocardiographic findings, and MCE parameters were 
      compared between the two groups. The accuracy of MCE parameters in the diagnosis 
      of LVDD and their correlations with characteristics of T2DM were evaluated. 
      RESULTS: In the LVDD+ group, the Axbeta (derived from the replenishment curve of 
      MCE, presenting myocardial blood flow) was significantly lower, and the HbA1c and 
      diabetes duration were significantly higher compared to the LVDD- group (all P < 
      0.05). The decrease of Axbeta helped warn the occurrence of LVDD although it was not 
      suitable for the independent diagnosis of LVDD (AUC = 0.745). Axbeta was negatively 
      correlated with diabetes duration and HbA1c (r = -0.350 and -0.226, both P < 
      0.001). CONCLUSION: MCE was feasible for detecting MP abnormalities in 
      asymptomatic T2DM patients. Although the Axbeta values of T2DM patients with 
      subclinical LVDD were better than those with diagnosed LVDD, it impaired with the 
      increase of HbA1c and diabetes duration. It suggested that MCE might be useful 
      for monitoring glycemic control in T2DM patients with DCM.
CI  - (c) 2021 Liu et al.
FAU - Liu, Yi
AU  - Liu Y
AD  - Department of Ultrasonography, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
FAU - Ma, Jing
AU  - Ma J
AD  - Division of Cardiology, Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan 
      University, Shanghai, People's Republic of China.
FAU - Guo, Jia
AU  - Guo J
AUID- ORCID: 0000-0002-6401-7050
AD  - Department of Ultrasonography, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
FAU - Lu, Hao
AU  - Lu H
AD  - Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University 
      of Traditional Chinese Medicine, Shanghai, People's Republic of China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Ultrasonography, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
FAU - Chen, Yilei
AU  - Chen Y
AD  - Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University 
      of Traditional Chinese Medicine, Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20211102
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC8572094
OTO - NOTNLM
OT  - HbA1c
OT  - diabetes duration
OT  - diabetic cardiomyopathy
OT  - left ventricular diastolic dysfunction
OT  - myocardial perfusion
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/11/11 06:00
MHDA- 2021/11/11 06:01
PMCR- 2021/11/02
CRDT- 2021/11/10 06:39
PHST- 2021/09/22 00:00 [received]
PHST- 2021/10/26 00:00 [accepted]
PHST- 2021/11/10 06:39 [entrez]
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2021/11/11 06:01 [medline]
PHST- 2021/11/02 00:00 [pmc-release]
AID - 340642 [pii]
AID - 10.2147/IJGM.S340642 [doi]
PST - epublish
SO  - Int J Gen Med. 2021 Nov 2;14:7533-7543. doi: 10.2147/IJGM.S340642. eCollection 
      2021.