PMID- 34754627 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211111 IS - 2167-8359 (Print) IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 9 DP - 2021 TI - Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis. PG - e12384 LID - 10.7717/peerj.12384 [doi] LID - e12384 AB - Interleukin-1 (IL-1) plays an essential role in the immune pro-inflammatory process, which is regarded as one of many factors in the development of type 2 diabetes mellitus (T2DM). Several case-control studies have illustrated the association of the IL-1B (-511) (rs16944, Chr 2:112,837,290, C/T Intragenic, Transition Substitution) and IL-1RN (VNTR) (gene for IL-1 receptor antagonist, IL-1RA, 86 bp tandem repeats in intron 2) polymorphisms with T2DM risk. However, the results were inconsistent and inconclusive. We performed a meta-analysis (registry number: CRD42021268494) to assess the association of the IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk. Random-effects models were applied to calculate the pooled ORs (odds ratios) and 95% CIs (confidence intervals) to test the strength of the association in the overall group and subgroups stratified by ethnicity, respectively. Between-study heterogeneity and publication bias were evaluated by the Q-test, I(2) statistic, Harbord test, and Peters test accordingly. Sensitivity analyses were also performed. A total of 12 publications evaluating the association of IL-1B (-511) and IL-1RN (VNTR) polymorphisms with the risk of T2DM development were included. The meta-analysis showed that IL-1RN (VNTR) was related to the increasing development of T2DM risk in the recessive model (OR = 1.62, 95% CI [1.09-2.42], P(het) = 0.377, P(z) = 0.018) and in the homozygous model (OR = 2.02, 95% CI [1.07-3.83], P(het) = 0.085, P(z) = 0.031), and the IL-1RN 2* allele was found a significant association with evaluated T2DM risk in all ethnicities (OR = 2.08, 95% CI [1.43-3.02], P(het) < 0.001, P(z) < 0.001) and in EA (OR = 2.01, 95% CI [1.53-2.66], P(het) = 0.541, P(z) < 0.001). Moreover, stratification by ethnicity revealed that IL-1B (-511) was associated with a decreased risk of T2DM in the dominant model (OR=0.76, 95% CI [0.59-0.97], P(het) = 0.218, P (z) = 0.027) and codominant model (OR = 0.73, 95% CI [0.54-0.99], P(het) = 0.141, P(z) = 0.040) in the East Asian (EA) subgroup. Our results suggest that the IL-1RN 2* allele and 2*2* homozygous polymorphism are strongly associated with increasing T2DM risk and that the IL-1B (-511) T allele polymorphism is associated with decreasing T2DM risk in the EA subgroup. CI - (c)2021 Jiao et al. FAU - Jiao, Juan AU - Jiao J AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. AD - Department of Clinical Laboratory, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China. FAU - Wang, Zhaoping AU - Wang Z AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Guo, Yanfei AU - Guo Y AD - Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P.R. China. FAU - Liu, Jie AU - Liu J AD - Department of Clinical Laboratory, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China. FAU - Huang, Xiuqing AU - Huang X AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Ni, Xiaolin AU - Ni X AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Gao, Danni AU - Gao D AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. AD - Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, China. FAU - Sun, Liang AU - Sun L AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Zhu, Xiaoquan AU - Zhu X AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Zhou, Qi AU - Zhou Q AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Yang, Ze AU - Yang Z AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. FAU - Yuan, Huiping AU - Yuan H AD - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China. LA - eng PT - Journal Article DEP - 20211025 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 PMC - PMC8552784 OTO - NOTNLM OT - IL-1B (-511) OT - IL-1RN (VNTR) OT - Meta-analysis OT - Polymorphism OT - Type 2 diabetes mellitus COIS- The authors declare there are no competing interests. EDAT- 2021/11/11 06:00 MHDA- 2021/11/11 06:01 PMCR- 2021/10/25 CRDT- 2021/11/10 06:43 PHST- 2021/07/27 00:00 [received] PHST- 2021/10/04 00:00 [accepted] PHST- 2021/11/10 06:43 [entrez] PHST- 2021/11/11 06:00 [pubmed] PHST- 2021/11/11 06:01 [medline] PHST- 2021/10/25 00:00 [pmc-release] AID - 12384 [pii] AID - 10.7717/peerj.12384 [doi] PST - epublish SO - PeerJ. 2021 Oct 25;9:e12384. doi: 10.7717/peerj.12384. eCollection 2021.