PMID- 34754899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 37
DP  - 2021 Dec
TI  - Therapeutic responsiveness to vagus nerve stimulation in patients receiving 
      beta-blockade for heart failure with reduced ejection fraction.
PG  - 100888
LID - 10.1016/j.ijcha.2021.100888 [doi]
LID - 100888
AB  - BACKGROUND: The effect of beta-blockade (BB) on response to vagus nerve 
      stimulation (VNS) has not been reported in patients with heart failure and 
      reduced ejection fraction (HFrEF). In the ANTHEM-HF Study, 60 patients received 
      chronic cervical VNS. Background pharmacological therapy remained unchanged 
      during the study, and VNS intensity was stable once up-titrated. Significant 
      improvement from baseline occurred in resting 24-hour heart rate (HR), 24-hour HR 
      variability (SDNN), left ventricular EF (LVEF), 6-minute walk distance (6MWD), 
      and quality of life (MLWHFS) at 6 months post-titration. We evaluated whether 
      response to VNS was related to percentage of target BB dose (PTBBD) at baseline. 
      METHODS: Patients were categorized by baseline PTBBD, then analyzed for changes 
      from baseline in symptoms and function at 6 months after VNS titration. RESULTS: 
      All patients received BB, either PTBBD >/= 50 % (16 patients, 27 %; group 1) or 
      PTBBD < 50 % (44 patients, 73 %; group 2). Heart rate, systolic blood pressure, 
      LVEF, use of ACE/ARB, and use of MRA were similar between the two groups at 
      baseline. Six months after up-titration, VNS reduced HR and significantly 
      improved SDNN, LVEF, 6MWD, and MLWHFS equally in both groups. CONCLUSIONS: In the 
      ANTHEM-HF study, VNS responsiveness appeared to be independent of the baseline BB 
      dose administered.
CI  - (c) 2021 The Authors. Published by Elsevier B.V.
FAU - Dede, Enea
AU  - Dede E
AD  - Charite Universitatsmedizin Berlin, Germany.
FAU - Gregory, Douglas D
AU  - Gregory DD
AD  - Clinical Cardiovascular Science Foundation, Boston, USA.
FAU - Ardell, Jeffrey L
AU  - Ardell JL
AD  - University of California at Los Angeles, Los Angeles, USA.
FAU - Libbus, Imad
AU  - Libbus I
AD  - LivaNova USA, Inc., Houston, USA.
FAU - DiCarlo, Lorenzo A
AU  - DiCarlo LA
AD  - LivaNova USA, Inc., Houston, USA.
FAU - Premchand, Rajendra K
AU  - Premchand RK
AD  - Krishna Institute of Medical Sciences, Secunderabad, India.
FAU - Sharma, Kamal
AU  - Sharma K
AD  - Sanjivani Super Specialty Hospitals, Ahmedabad, India.
FAU - Mittal, Sanjay
AU  - Mittal S
AD  - Medanta, The Medicity, Haryana, India.
FAU - Monteiro, Rufino
AU  - Monteiro R
AD  - Vintage Hospital, Goa, India.
FAU - Anand, Inder S
AU  - Anand IS
AD  - University of Minnesota, Minneapolis, USA.
FAU - Dungen, Hans-Dirk
AU  - Dungen HD
AD  - Charite Universitatsmedizin Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20211020
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC8556756
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Autonomic regulation therapy
OT  - Beta blockers
OT  - Heart failure
OT  - Sympathetic blockade
OT  - Vagus nerve stimulation
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/11/11 06:00
MHDA- 2021/11/11 06:01
PMCR- 2021/10/20
CRDT- 2021/11/10 06:45
PHST- 2021/05/27 00:00 [received]
PHST- 2021/08/19 00:00 [revised]
PHST- 2021/10/06 00:00 [accepted]
PHST- 2021/11/10 06:45 [entrez]
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2021/11/11 06:01 [medline]
PHST- 2021/10/20 00:00 [pmc-release]
AID - S2352-9067(21)00176-7 [pii]
AID - 100888 [pii]
AID - 10.1016/j.ijcha.2021.100888 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2021 Oct 20;37:100888. doi: 
      10.1016/j.ijcha.2021.100888. eCollection 2021 Dec.