PMID- 34755187 OWN - NLM STAT- MEDLINE DCOM- 20220823 LR - 20220823 IS - 1439-7609 (Electronic) IS - 1439-7595 (Linking) VI - 32 IP - 5 DP - 2022 Aug 20 TI - A nationwide questionnaire survey on the prevalence of ankylosing spondylitis and non-radiographic axial spondyloarthritis in Japan. PG - 960-967 LID - 10.1093/mr/roab096 [doi] AB - OBJECTIVE: This nationwide study aimed to reveal the prevalence of ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis (nr-ax SpA), and the positivity rate of human leukocyte antigen (HLA) among such patients in Japan. METHODS: The first survey was conducted in 2221 randomly selected facilities (26.3%) in September 2018, where the patients with AS/nr-ax SpA were taken care of from January to December 2017. We estimated the total number of these patients using response and extraction rates. A second survey was conducted in 117 facilities (49.8%) to assess for HLA-B27 positivity rate and clinical features. RESULTS: The estimated total numbers of the patients with AS and nr-ax SpA were 3200 (95% confidence interval [CI]: 2400-3900) and 800 (530-1100), suggesting that the prevalence values of AS and nr-ax SpA in general population were 2.6/100,000 (0.0026%) and 0.6/100,000 (0.0006%), respectively. Although 55.5% (76/137) of patients with AS were HLA-B27-positive, those whose age of onset was estimated to be over 50 years tended to undergo less HLA-B27 testing. CONCLUSION: This study revealed the lower prevalence of AS/nr-ax SpA in Japan, compared to those in other countries. Further studies are required to reveal the association of HLA-B27 with the clinical features. CI - (c) Japan College of Rheumatology 2021. Published by Oxford University Press. FAU - Matsubara, Yuri AU - Matsubara Y AUID- ORCID: 0000-0003-4593-2066 AD - Department of Public Health, Jichi Medical University, Tochigi, Japan. FAU - Nakamura, Yosikazu AU - Nakamura Y AD - Department of Public Health, Jichi Medical University, Tochigi, Japan. FAU - Tamura, Naoto AU - Tamura N AD - Department of Rheumatology and Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan. FAU - Kameda, Hideto AU - Kameda H AD - Division of Rheumatology, Department of Internal Medicine, Toho University, Tokyo, Japan. FAU - Otomo, Kotaro AU - Otomo K AD - Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. FAU - Kishimoto, Mitsumasa AU - Kishimoto M AD - Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan. FAU - Kadono, Yuho AU - Kadono Y AD - Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan. FAU - Tsuji, Shigeyoshi AU - Tsuji S AD - Department of Orthopaedics and Rheumatology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan. FAU - Atsumi, Tatsuya AU - Atsumi T AD - Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University, Sapporo, Hokkaido, Japan. FAU - Matsuno, Hiroaki AU - Matsuno H AD - Matsuno Clinic for Rheumatic Diseases, Toyama, Japan. FAU - Takagi, Michiaki AU - Takagi M AD - Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan. FAU - Kobayashi, Shigeto AU - Kobayashi S AD - Department of Internal Medicine and Rheumatology, Juntendo University Koshigaya Hospital, Saitama, Japan. FAU - Fujio, Keishi AU - Fujio K AD - Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. FAU - Nishimoto, Norihiro AU - Nishimoto N AD - Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan. AD - Osaka Rheumatology Clinic, Osaka, Japan. FAU - Okamoto, Nami AU - Okamoto N AD - Department of Pediatrics, Osaka Medical College, Osaka, Japan. FAU - Nakajima, Ayako AU - Nakajima A AD - Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan. FAU - Matsui, Kiyoshi AU - Matsui K AD - Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Yamamura, Masahiro AU - Yamamura M AD - Center for Rheumatology, Okayama Saiseikai General Hospital, Okayama, Japan. FAU - Nakashima, Yasuharu AU - Nakashima Y AD - Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan. FAU - Kawakami, Atsushi AU - Kawakami A AD - Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. FAU - Mori, Masaaki AU - Mori M AD - Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. FAU - Tomita, Tetsuya AU - Tomita T AD - Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan. LA - eng GR - diagnostic guidance for nr-axSpA in Japan/ PT - Journal Article PL - England TA - Mod Rheumatol JT - Modern rheumatology JID - 100959226 RN - 0 (HLA-B27 Antigen) SB - IM MH - *Axial Spondyloarthritis MH - HLA-B27 Antigen MH - Humans MH - Japan/epidemiology MH - Middle Aged MH - *Non-Radiographic Axial Spondyloarthritis MH - Prevalence MH - *Spondylarthritis/diagnostic imaging/epidemiology MH - *Spondylitis, Ankylosing/diagnostic imaging/epidemiology MH - Surveys and Questionnaires OTO - NOTNLM OT - Ankylosing spondylitis OT - nationwide survey OT - non-radiographic axial spondyloarthritis OT - the prevalence EDAT- 2021/11/11 06:00 MHDA- 2022/08/24 06:00 CRDT- 2021/11/10 06:50 PHST- 2021/08/06 00:00 [received] PHST- 2021/10/17 00:00 [revised] PHST- 2021/10/21 00:00 [accepted] PHST- 2021/11/11 06:00 [pubmed] PHST- 2022/08/24 06:00 [medline] PHST- 2021/11/10 06:50 [entrez] AID - 6424615 [pii] AID - 10.1093/mr/roab096 [doi] PST - ppublish SO - Mod Rheumatol. 2022 Aug 20;32(5):960-967. doi: 10.1093/mr/roab096.