PMID- 34755374
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 82
IP  - 1
DP  - 2022 Feb
TI  - 6-Shogaol improves behavior and memory in Wistar rats prenatally exposed to 
      lipopolysaccharide.
PG  - 39-49
LID - 10.1002/jdn.10157 [doi]
AB  - OBJECTIVE: 6-Shogaol, bioactive compound of Zingiber officinale Roscoe, has 
      anti-inflammatory, antioxidant, and neuroprotective properties. The objective of 
      the present study was to verify the effect of 6-shogaol on behavioral parameters 
      in a preclinical model based on a maternal immune activation (MIA) by 
      lipopolysaccharide (LPS). METHODOLOGY: Twelve pregnant Wistar rats received 
      100-mug/kg LPS or saline solution on gestational day (GD) 9.5. Male offspring 
      participated in the study and in the postnatal day (PND) 30 and 55 were 
      supplemented with 6-shogaol or saline solution, by gavage at a dose of 
      10 mg/kg/day, orally for 5 days. In the PND 35 and 60 was performed the 
      behavioral tests: grooming, crossing, and rearing that evaluated repetitive 
      movements, anxiety, and interest in the new, respectively, and the inhibitory 
      avoidance test that evaluated short-term (STM) and long-term memory (LTM). 
      RESULT: Prenatal exposure to LPS increased the grooming and crossing episodes at 
      different ages and reduced rearing episodes in PND 37. Treatment with 6-shogaol 
      reversed these parameters. In the inhibitory avoidance test, an improvement of 
      memory was identified with 6-shogaol in the STM and LTM at both ages comparing 
      training and test session of treated groups and between groups. CONCLUSION: 
      Administration of 6-shogaol reverses the stereotypy, exploratory behavior, and 
      memory impairment in prenatal LPS-exposed offspring, acting as a promising 
      therapeutic component against brain disorders associated with the process of MIA.
CI  - (c) 2021 International Society for Developmental Neuroscience.
FAU - da Rosa, Naiana
AU  - da Rosa N
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - de Medeiros, Fabiana Durante
AU  - de Medeiros FD
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - de Oliveira, Juliana
AU  - de Oliveira J
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - Laurentino, Ana Olivia Martins
AU  - Laurentino AOM
AUID- ORCID: 0000-0002-5797-8443
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - Peretti, Eduardo Medeiros
AU  - Peretti EM
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - Machado, Richard Simon
AU  - Machado RS
AUID- ORCID: 0000-0002-2329-0501
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - Fortunato, Jucelia Jeremias
AU  - Fortunato JJ
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
FAU - Petronilho, Fabricia
AU  - Petronilho F
AUID- ORCID: 0000-0003-3240-2808
AD  - Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate 
      Program in Health Sciences, Health Sciences Unit, University of Southern Santa 
      Catarina (UNISUL), Tubarao, Brazil.
LA  - eng
GR  - National Council for Scientific and Technological Development/
PT  - Journal Article
DEP - 20211123
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Catechols)
RN  - 0 (Lipopolysaccharides)
RN  - 83DNB5FIRF (shogaol)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Catechols/pharmacology
MH  - Female
MH  - *Lipopolysaccharides/toxicity
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - 6-shogaol
OT  - autism
OT  - behavior
OT  - lipopolysaccharide
OT  - maternal immune activation
OT  - memory
EDAT- 2021/11/11 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/11/10 06:59
PHST- 2021/10/27 00:00 [revised]
PHST- 2021/07/30 00:00 [received]
PHST- 2021/11/05 00:00 [accepted]
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/11/10 06:59 [entrez]
AID - 10.1002/jdn.10157 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2022 Feb;82(1):39-49. doi: 10.1002/jdn.10157. Epub 2021 Nov 
      23.