PMID- 34755819
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20211119
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Print)
IS  - 0074-0276 (Linking)
VI  - 116
DP  - 2021
TI  - Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 
      1954 to 2019.
PG  - e210203
LID - S0074-02762021000101100 [pii]
LID - 10.1590/0074-02760210203 [doi]
LID - e210203
AB  - BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin 
      America. Etiological agents are Paracoccidioides species that diverge 
      phylogenetically throughout South America. OBJECTIVES: This study aimed to 
      document the epidemiology of PCM in Venezuela. METHODS: We have performed a 
      retrospective cross-sectional descriptive study in 31,081 clinical records of 
      patients from two reference centres during 65 years (1954-2019). FINDINGS: PCM 
      diagnosis was confirmed in 745 patients. Chronic PCM was the most prevalent form 
      (90.06% cases); 80.67% were male and the most affected age range was 41-60. 
      Farming and construction were the most prevalent occupation and Miranda State had 
      a higher prevalence. Lung and skin were the most affected organs, followed by 
      oral manifestations. Direct examination, culture and serology showed a high 
      sensibility, and no statistical difference was observed among the diagnostic 
      tools. Out of 17 Paracoccidioides isolates genotyped from Venezuela, one was 
      typed as Paracoccidioides americana and 16 as Paracoccidioides venezuelensis. 
      MAIN CONCLUSIONS: Clinical manifestations observed, information about the 
      epidemiology and molecular profile is essential not only for diagnosis but also 
      for understanding therapeutic responses to mycotic drugs and prognosis. 
      Therefore, it is necessary to sequence all positive isolated strains in order to 
      confirm the dominance of P. venezuelensis in Venezuela.
FAU - Alvarado, Primavera
AU  - Alvarado P
AUID- ORCID: 0000-0002-5965-6827
AD  - Instituto Autonomo de Biomedicina Dr Jacinto Convit, Laboratorio de Micologia, 
      Caracas, Miranda, Venezuela.
AD  - Universidad Central de Venezuela, Facultad de Medicina, Caracas, Miranda, 
      Venezuela.
FAU - Teixeira, Marcus de Melo
AU  - Teixeira MM
AD  - Universidade de Brasilia, Faculdade de Medicina, Brasilia, DF, Brasil.
FAU - Cavallera, Elsy
AU  - Cavallera E
AD  - Instituto Autonomo de Biomedicina Dr Jacinto Convit, Laboratorio de Micologia, 
      Caracas, Miranda, Venezuela.
FAU - Paes, Hugo Costa
AU  - Paes HC
AD  - Universidade de Brasilia, Faculdade de Medicina, Brasilia, DF, Brasil.
FAU - Guerra, Giovanni
AU  - Guerra G
AD  - Instituto Autonomo de Biomedicina Dr Jacinto Convit, Laboratorio de Micologia, 
      Caracas, Miranda, Venezuela.
FAU - Santander, Gerardo
AU  - Santander G
AD  - Universidad Central de Venezuela, Instituto de Geografia Regional, Caracas, 
      Miranda, Venezuela.
FAU - Merino-Alado, Rommie
AU  - Merino-Alado R
AD  - Universidad Central de Venezuela, Facultad de Odontologia, Caracas, Miranda, 
      Venezuela.
LA  - eng
PT  - Journal Article
DEP - 20211108
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Male
MH  - *Paracoccidioides/genetics
MH  - *Paracoccidioidomycosis/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Venezuela/epidemiology
PMC - PMC8577064
EDAT- 2021/11/11 06:00
MHDA- 2021/11/12 06:00
PMCR- 2021/11/08
CRDT- 2021/11/10 09:13
PHST- 2021/06/09 00:00 [received]
PHST- 2021/09/21 00:00 [accepted]
PHST- 2021/11/10 09:13 [entrez]
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/11/08 00:00 [pmc-release]
AID - S0074-02762021000101100 [pii]
AID - 10.1590/0074-02760210203 [doi]
PST - epublish
SO  - Mem Inst Oswaldo Cruz. 2021 Nov 8;116:e210203. doi: 10.1590/0074-02760210203. 
      eCollection 2021.