PMID- 34755932
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 36
IP  - 2
DP  - 2022 Feb
TI  - Data on multiple regression analysis between boron, nickel, arsenic, antimony, 
      and biological substrates in horses: The role of hematological biomarkers.
PG  - e22955
LID - 10.1002/jbt.22955 [doi]
AB  - The objective of this study was to evaluate the biomarkers of exposure to boron, 
      nickel, arsenic, and antimony in an industrial region, evaluating the 
      bioaccumulation in biological substrates and the correlation with biomarkers such 
      as hematological parameters. Through indication of the accumulation of some 
      minerals in the horse's biological substrates reflects environmental pollution. 
      Moreover, an additional aim of the study was to show whether these contaminants 
      have an influence on the hematological parameters in horses. Blood, serum, mane, 
      and tail samples from 20 horses from an industrial area were analyzed to 
      determine boron (B), nickel (Ni), arsenic (As), antimony (Sb) concentration. 
      Hematological parameters (red blood cell [RBC], white blood cells [WBC], 
      hemoglobin [Hb], hematocrit [Hct], mean corpuscular volume [MCV], mean 
      corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC], 
      platelet [PLT]) as a biomarker of blood in relation to the bioaccumulation of 
      these elements were analyzed also. Descriptive statistical analysis was performed 
      and single regression analysis (Pearson) and multiple regression analysis 
      (p < 0.05) between blood factors, As, B, Ni, and Sb concentrations, and for each 
      mineral in different substrate, respectively. Results showed a significant 
      correlation between tail and mane concentrations with serum and blood for boron 
      concentration (r = -1 p < 0.05). No significant correlation between sample (feed, 
      hay, mane, tail, and water) concentrations and As, Ni, and Sb were found. A 
      significantly negative correlation with blood parameters (r = -1 p < 0.05) was 
      observed in Boron concentration for mane and tail. This suggests that the mane 
      and tail may be a potential means to investigate suspected exposure to excessive 
      levels of trace minerals.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Giannetto, Claudia
AU  - Giannetto C
AD  - Department of Veterinary Science, University of Messina, Messina, Italy.
FAU - Fazio, Francesco
AU  - Fazio F
AD  - Department of Veterinary Science, University of Messina, Messina, Italy.
FAU - Nava, Vincenzo
AU  - Nava V
AD  - BioMorf Department, University of Messina, Messina, Italy.
FAU - Arfuso, Francesca
AU  - Arfuso F
AD  - Department of Veterinary Science, University of Messina, Messina, Italy.
FAU - Piccione, Giuseppe
AU  - Piccione G
AD  - Department of Veterinary Science, University of Messina, Messina, Italy.
FAU - Coelho, Clarisse
AU  - Coelho C
AD  - Faculty of Veterinary Medicine, Lusofona University, Lisbon, Portugal.
FAU - Gugliandolo, Enrico
AU  - Gugliandolo E
AD  - Department of Veterinary Science, University of Messina, Messina, Italy.
FAU - Licata, Patrizia
AU  - Licata P
AD  - Department of Veterinary Science, University of Messina, Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20211110
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Biomarkers)
RN  - 7OV03QG267 (Nickel)
RN  - 9IT35J3UV3 (Antimony)
RN  - N712M78A8G (Arsenic)
RN  - N9E3X5056Q (Boron)
SB  - IM
MH  - Animals
MH  - Antimony/*blood
MH  - Arsenic
MH  - Biomarkers/blood
MH  - Boron/*blood
MH  - Hematocrit
MH  - Horses/*blood
MH  - Nickel/*blood
OTO - NOTNLM
OT  - blood biomarkers
OT  - horse
OT  - mineral element
OT  - multiple regression analysis
EDAT- 2021/11/11 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/11/10 09:20
PHST- 2021/09/28 00:00 [revised]
PHST- 2021/05/12 00:00 [received]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/11/10 09:20 [entrez]
AID - 10.1002/jbt.22955 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2022 Feb;36(2):e22955. doi: 10.1002/jbt.22955. Epub 2021 
      Nov 10.