PMID- 3475724
OWN - NLM
STAT- MEDLINE
DCOM- 19870828
LR  - 20211203
IS  - 0262-1746 (Print)
IS  - 0262-1746 (Linking)
VI  - 27
IP  - 2-3
DP  - 1987 May
TI  - Alteration of mercuric chloride-induced autoimmune glomerulonephritis in 
      brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective 
      TXA-synthetase inhibitor.
PG  - 129-49
AB  - Repeated subcutaneous (SC) injections of mercuric chloride (MC) in Brown Norway 
      (BN) rats induce an autoimmune glomerulonephritis (GN) due to antiglomerular 
      basement membrane (BM) antibody deposition in the glomeruli. The aim of this 
      study was to investigate the effects on MC-induced autoimmune GN of OKY-046, a 
      selective TXA-synthetase inhibitor herring oil (HO), which is rich in 
      eicosapentaenoic acid (EPA) (5.6%) precursor of the three series of 
      prostaglandins (PGs) and of (inactive) thromboxane (TXA3), and evening primrose 
      oil (EPO), which is rich in linoleic acid (LA) (72%) and gamma-linolenic acid 
      (GLNA) (9%), precursors of the one series of PGs, mainly PGE1, and of (inactive) 
      TXA1. The administration of OKY-046 significantly inhibited proteinuria, 
      partially prevented fibrin thrombi (FT) formation in the glomeruli, decreased 
      urinary TXB, enhanced 6ketoPGF excretion and, increased survival rate of the 
      animals from 60% (group receiving only MC) to 86%. However, OKY-046 did not 
      prevent body weight (BW) loss or the development and deposition of IgG in the 
      glomeruli. Increased intake of HO (80 days prior and throughout the experiment) 
      and avoidance of arachidonic acid (AA) intake produced an effect comparable to 
      that of OKY-046 in the rats. Furthermore, HO significantly inhibited the 
      deposition of IgG in the glomeruli, increased the survival rate of the animals to 
      100% and further enhanced the increased urinary PGE excretion induced by MC. 
      However, HO did not prevent BW loss in the animals. Increased intake of EPO and 
      avoidance of AA intake produced an effect comparable to that of HO. Additionally, 
      EPO completely prevented BW loss induced by MC in these animals. These findings 
      suggest that the metabolites of AA, EPA and GLNA play an important role either in 
      the development or in the modulation of this model of MC induced GN.
FAU - Papanikolaou, N
AU  - Papanikolaou N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Scotland
TA  - Prostaglandins Leukot Med
JT  - Prostaglandins, leukotrienes, and medicine
JID - 8206868
RN  - 0 (Acrylates)
RN  - 0 (Fatty Acids, Essential)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Fish Oils)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Linoleic Acids)
RN  - 0 (Methacrylates)
RN  - 0 (Plant Oils)
RN  - 0 (Prostaglandins E)
RN  - 0 (Thromboxanes)
RN  - 3Q9L08K71N (evening primrose oil)
RN  - 53GH7MZT1R (Mercuric Chloride)
RN  - 58962-34-8 (6-Ketoprostaglandin F1 alpha)
RN  - 78YC2MAX4O (gamma-Linolenic Acid)
RN  - EC 5.3.99.5 (Thromboxane-A Synthase)
RN  - L256JB984D (ozagrel)
SB  - IM
MH  - 6-Ketoprostaglandin F1 alpha/urine
MH  - Acrylates/*therapeutic use
MH  - Animals
MH  - Autoimmune Diseases/*prevention & control
MH  - *Fatty Acids, Essential
MH  - Fatty Acids, Unsaturated/*therapeutic use
MH  - Fish Oils/*therapeutic use
MH  - Glomerulonephritis/*prevention & control
MH  - Hypolipidemic Agents/*therapeutic use
MH  - Immunoglobulin G/metabolism
MH  - Linoleic Acids
MH  - Mercuric Chloride
MH  - Methacrylates/*therapeutic use
MH  - Oenothera biennis
MH  - Plant Oils
MH  - Prostaglandins E/urine
MH  - Proteinuria/prevention & control
MH  - Rats
MH  - Thromboxane-A Synthase/*antagonists & inhibitors/pharmacology
MH  - Thromboxanes/urine
MH  - gamma-Linolenic Acid
EDAT- 1987/05/01 00:00
MHDA- 1987/05/01 00:01
CRDT- 1987/05/01 00:00
PHST- 1987/05/01 00:00 [pubmed]
PHST- 1987/05/01 00:01 [medline]
PHST- 1987/05/01 00:00 [entrez]
AID - 10.1016/0262-1746(87)90066-7 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Med. 1987 May;27(2-3):129-49. doi: 
      10.1016/0262-1746(87)90066-7.