PMID- 34758056
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220508
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Print)
IS  - 1090-820X (Linking)
VI  - 42
IP  - 4
DP  - 2022 Mar 15
TI  - Hyaluronic Acid Compound Filling Plus Mesotherapy vs Botulinum Toxin A for the 
      Treatment of Horizontal Neck Lines: A Multicenter, Randomized, Evaluator-Blinded, 
      Prospective Study in Chinese Subjects.
PG  - NP230-NP241
LID - 10.1093/asj/sjab387 [doi]
AB  - BACKGROUND: Although energy devices and botulinum toxin A (BTX-A) can alleviate 
      age-related laxity, ptosis, and platysmal bands, they have limited efficacy on 
      horizontal neck lines. OBJECTIVES: The purpose of this study was to investigate 
      the efficacy, safety, and subject satisfaction of a combined treatment of 
      non-cross-linked hyaluronic acid (HA) compound filling plus mesotherapy for the 
      correction of horizontal neck lines, in comparison with BTX-A. METHODS: This 
      multicenter, randomized, evaluator-blinded, prospective study enrolled female 
      patients with moderate-to-severe horizontal neck lines corrected with either 2 or 
      3 sessions of of non-cross-linked HA compound filling plus mesotherapy or 1 
      session of BTX-A injection. Improvement of the neck lines grades, Global 
      Aesthetic Improvement Scale (GAIS), patient satisfaction, and adverse events 
      (AEs) were evaluated and compared at 1, 3, 6, and 10 months after the final 
      treatment. RESULTS: Twenty-five patients received HA filling plus mesotherapy and 
      23 received BTX-A injection. Compared with BTX-A, the HA compound filling plus 
      mesotherapy significantly improved the horizontal neck lines grades on all 
      follow-up visits (P = 0.000). Cases of different baseline grades (2, 2.5, and 3) 
      demonstrated similar outcomes. The GAIS and patients' satisfaction ratings were 
      significantly higher for the HA filling plus mesotherapy treatment group 
      (P = 0.000). Significantly higher pain ratings, higher incidence, and longer 
      recovery of AEs (erythema, edema, and ecchymosis) were noticed in the combined 
      treatment group (P < 0.001). No serious AEs occurred. CONCLUSIONS: Compared with 
      BTX-A, combined treatment with HA compound filling plus mesotherapy significantly 
      improved moderate-to-severe horizontal neck lines and achieved a high level of 
      patient satisfaction.
CI  - (c) 2021 The Aesthetic Society.
FAU - Li, Yiming
AU  - Li Y
AD  - Department of Dermatology and Venerology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Liao, Meirong
AU  - Liao M
AD  - Department of Dermatology, Sichuan FreSkin Hospital, Chengdu, Sichuan, China.
FAU - Zhu, Yijin
AU  - Zhu Y
AD  - Department of Dermatology, Sichuan FreSkin Hospital, Chengdu, Sichuan, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of Dermatology, Sichuan FreSkin Hospital, Chengdu, Sichuan, China.
FAU - Song, Yang
AU  - Song Y
AD  - Department of Dermatology, Xian FreSkin Hospital, Xian, Shanxi, China.
FAU - Zhai, Yang
AU  - Zhai Y
AD  - Department of Dermatology, Xian FreSkin Hospital, Xian, Shanxi, China.
FAU - Zhu, Miao
AU  - Zhu M
AD  - Department of Dermatology, Changsha FreSkin Hospital, Changsha, Hunan, China.
FAU - He, Yan
AU  - He Y
AD  - Department of Dermatology, Chongqing FreSkin Hospital, Chongqing, China.
FAU - Dong, Weiwei
AU  - Dong W
AUID- ORCID: 0000-0001-7299-7100
AD  - Department of Plastic Surgery, Sichuan FreSkin Hospital, Chengdu, Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
SB  - IM
CIN - Aesthet Surg J. 2022 Mar 15;42(4):NP242-NP243. PMID: 35289354
EIN - Aesthet Surg J. 2022 Apr 02;:. PMID: 35365831
MH  - *Botulinum Toxins, Type A/adverse effects
MH  - China
MH  - *Cosmetic Techniques/adverse effects
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/adverse effects
MH  - *Mesotherapy
MH  - Prospective Studies
MH  - *Skin Aging
MH  - Treatment Outcome
PMC - PMC8972830
EDAT- 2021/11/11 06:00
MHDA- 2022/04/06 06:00
PMCR- 2021/11/10
CRDT- 2021/11/10 18:03
PHST- 2021/11/11 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2021/11/10 18:03 [entrez]
PHST- 2021/11/10 00:00 [pmc-release]
AID - 6425097 [pii]
AID - sjab387 [pii]
AID - 10.1093/asj/sjab387 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2022 Mar 15;42(4):NP230-NP241. doi: 10.1093/asj/sjab387.