PMID- 34759603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 0973-2284 (Print)
IS  - 1998-3670 (Electronic)
IS  - 0973-2284 (Linking)
VI  - 25
IP  - 3
DP  - 2021 Jul-Sep
TI  - Persistent organic pollutants-environmental risk factors for diabetes mellitus? - 
      A population-based study.
PG  - 157-162
LID - 10.4103/ijoem.ijoem_337_20 [doi]
AB  - BACKGROUND: Globally, type-2 diabetes mellitus is increasing in epidemic 
      proportions. A major cause of concern in India is the increasing incidence of 
      cases, especially troubling is the observed increase in younger age groups with 
      no risk factors. New evidence suggests that many environmental factors, such as 
      air pollution, persistent organic pollutants (POPs), and environmental estrogens 
      are implicated as risk factors for type-2 diabetes mellitus. Animal and human 
      epidemiological studies have shown ubiquitous lipophilic substances, including 
      POPs, are frequently associated with type-2 diabetes mellitus. Such studies have 
      not been undertaken in Indian youth. METHODS: This is a cross-sectional study 
      that explored the association between POPs and type-2 diabetes mellitus in Indian 
      urban and rural population. About 7 ml of venous blood was collected from all 
      consenting patients and serum was separated immediately and was transported to 
      the lab for further analysis. Serum levels of POPs, including organochlorine (OC) 
      compounds and organophosphorus pesticides, were estimated using sample gas 
      chromatography-mass spectrometry (GC-MS). The fasting blood sugar values and the 
      serum levels of POPS were tested using Pearson correlation coefficient. The 
      magnitude of increase in blood sugar corresponding to increase in POPs was 
      analyzed using linear regression analysis. The odds ratios (ORs) were expressed 
      at 95% confidence intervals (CIs). RESULTS: Three OC pesticides and one 
      organophosphate pesticide were strongly associated with increasing blood sugar 
      levels after adjusting for age, sex, and body mass index - lindane (OR 4.95, 95% 
      CI 1.03-23.73), DDT o, p' (OR 3.50, 95% CI 1.04-11.73), dimethoate (OR 19.31, 95% 
      CI 4.22-88.37), and dichlorvas (OR 6.33, 95% CI 1.28-31.18).
CI  - Copyright: (c) 2021 Indian Journal of Occupational and Environmental Medicine.
FAU - Ramalingam, Sudha
AU  - Ramalingam S
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
AD  - Department of Community Medicine, PSG Institute of Medical Sciences and Research, 
      Coimbatore, Tamil Nadu, India.
FAU - Narayanan, Ramanujam
AU  - Narayanan R
AD  - Department of Pharmacology, PSG Institute of Medical Sciences and Research, 
      Coimbatore, Tamil Nadu, India.
FAU - Muthusamy, Sivaselvakumar
AU  - Muthusamy S
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
FAU - Veronika, Merlin
AU  - Veronika M
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
FAU - Sankaran, Ramalingam
AU  - Sankaran R
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
AD  - Department of Pharmacology, PSG Institute of Medical Sciences and Research, 
      Coimbatore, Tamil Nadu, India.
FAU - Toscano, William
AU  - Toscano W
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      Minnesota, Minneapolis, Minnesota, USA.
LA  - eng
PT  - Journal Article
DEP - 20211009
PL  - India
TA  - Indian J Occup Environ Med
JT  - Indian journal of occupational and environmental medicine
JID - 9815775
PMC - PMC8559882
OTO - NOTNLM
OT  - DDT
OT  - dimethoate
OT  - health effects
OT  - persistent organic pollutants
OT  - pesticides
OT  - type- 2 diabetes mellitus.
COIS- There are no conflicts of interest.
EDAT- 2021/11/12 06:00
MHDA- 2021/11/12 06:01
PMCR- 2021/07/01
CRDT- 2021/11/11 06:51
PHST- 2020/08/27 00:00 [received]
PHST- 2020/11/16 00:00 [revised]
PHST- 2021/07/03 00:00 [accepted]
PHST- 2021/11/11 06:51 [entrez]
PHST- 2021/11/12 06:00 [pubmed]
PHST- 2021/11/12 06:01 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - IJOEM-25-157 [pii]
AID - 10.4103/ijoem.ijoem_337_20 [doi]
PST - ppublish
SO  - Indian J Occup Environ Med. 2021 Jul-Sep;25(3):157-162. doi: 
      10.4103/ijoem.ijoem_337_20. Epub 2021 Oct 9.