PMID- 34759889 OWN - NLM STAT- MEDLINE DCOM- 20220214 LR - 20220214 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 12 DP - 2021 TI - Aberrant Functional Connectivity of the Posterior Cingulate Cortex in Type 2 Diabetes Without Cognitive Impairment and Microvascular Complications. PG - 722861 LID - 10.3389/fendo.2021.722861 [doi] LID - 722861 AB - OBJECTIVE: We aimed to investigate the alterations of brain functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without clinical evidence of cognitive impairment and microvascular complications (woCIMC-T2DM) using resting-state functional MRI (rs-fMRI) and to determine whether its value was correlated with clinical indicators. METHODS: A total of 27 T2DM and 26 healthy controls (HCs) were prospectively examined. Cognitive impairment was excluded using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) scales, and microvascular complications were excluded by fundus photography, microalbuminuria, and other indicators. The correlation maps, derived from rs-fMRI with posterior cingulate cortex (PCC) as the seed, were compared between T2DM patients and HCs. Pearson's correlation analysis was performed to determine the relationship between the FC of PCC and the clinical indicators. RESULTS: Compared with HC, woCIMC-T2DM patients showed significantly decreased FCs with PCC (PCC-FCs) in the anterior cingulate cortex (ACC), right superior frontal gyrus, right medial frontal gyrus, and right angular gyrus. Meanwhile, increased PCC-FCs was observed in the right superior temporal gyrus and calcarine fissure (CAL). The FC of PCC-ACC was negatively correlated with glycosylated hemoglobin (HbA1c) and diabetes duration, and the FC of PCC-CAL was significantly positively correlated with HbA1c and diabetes duration. CONCLUSION: The FC, especially of the PCC with cognitive and visual brain regions, was altered before clinically measurable cognitive impairment and microvascular complications occurred in T2DM patients. In addition, the FC of the PCC with cognitive and visual brain regions was correlated with HbA1c and diabetes duration. This indicates that clinicians should pay attention not only to blood glucose control but also to brain function changes before the occurrence of adverse complications, which is of great significance for the prevention of cognitive dysfunction and visual impairment. CI - Copyright (c) 2021 Cheng, Song, Li, Zhang, Yi, Xu, Zhou and Zuo. FAU - Cheng, Panpan AU - Cheng P AD - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Song, Shuyan AU - Song S AD - College of Electrics and Information Engineering, South-Central University for Nationalities, Wuhan, China. FAU - Li, Yumin AU - Li Y AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zhang, Yao AU - Zhang Y AD - Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Yi, Jun AU - Yi J AD - Department of Psychiatry, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xu, Xiangyang AU - Xu X AD - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zhou, Hongmei AU - Zhou H AD - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zuo, Zhentao AU - Zuo Z AD - State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. AD - Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. AD - CAS Center for Excellence in Brain and Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211025 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Adult MH - Aged MH - Case-Control Studies MH - China MH - Cognitive Dysfunction/complications/diagnosis MH - Diabetes Mellitus, Type 2/complications/diagnosis/pathology/*psychology MH - Diabetic Angiopathies/diagnosis/pathology/psychology MH - Female MH - Gyrus Cinguli/diagnostic imaging/*pathology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Microvessels/diagnostic imaging/pathology MH - Middle Aged MH - Nerve Net/diagnostic imaging/*pathology MH - Neuropsychological Tests PMC - PMC8573207 OTO - NOTNLM OT - cognitive impairment OT - functional connectivity OT - posterior cingulum cortex OT - resting-state functional MRI OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/11/12 06:00 MHDA- 2022/02/15 06:00 PMCR- 2021/01/01 CRDT- 2021/11/11 06:53 PHST- 2021/07/08 00:00 [received] PHST- 2021/10/04 00:00 [accepted] PHST- 2021/11/11 06:53 [entrez] PHST- 2021/11/12 06:00 [pubmed] PHST- 2022/02/15 06:00 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2021.722861 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2021 Oct 25;12:722861. doi: 10.3389/fendo.2021.722861. eCollection 2021.