PMID- 34760322
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211112
IS  - 2090-6382 (Print)
IS  - 2090-6390 (Electronic)
IS  - 2090-6390 (Linking)
VI  - 2021
DP  - 2021
TI  - ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease.
PG  - 9914311
LID - 10.1155/2021/9914311 [doi]
LID - 9914311
AB  - Patients with mitochondrial disease exhibit disrupted pyruvate oxidation, 
      resulting in intraoperative and perioperative physiologic derangements. Increased 
      enzymatic conversion of pyruvate via lactate dehydrogenase during periods of 
      fasting or stress can lead to metabolic decompensation, with rapid development of 
      fatal lactic acidosis. We describe the intraoperative management and 
      postoperative critical care of a patient with mitochondrial disease who presented 
      for repair of esophageal perforation following repair of a paraesophageal hernia. 
      His surgery was complicated by the development of metabolic crisis and severe 
      lactic acidosis which became resistant to conventional therapy before ultimately 
      resolving with the initiation of venoarterial extracorporeal membrane oxygenation 
      (VA-ECMO).
CI  - Copyright (c) 2021 Sonal Sharma et al.
FAU - Sharma, Sonal
AU  - Sharma S
AUID- ORCID: 0000-0002-7163-5682
AD  - Department of Anesthesiology and Perioperative Medicine, Penn State Health, 
      Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
FAU - Deerman, Clifford
AU  - Deerman C
AD  - Department of Anesthesiology and Perioperative Medicine, Penn State Health, 
      Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
FAU - Andreae, Michael H
AU  - Andreae MH
AD  - Department of Anesthesiology and Perioperative Medicine, Penn State Health, 
      Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
FAU - Myler, Conrad
AU  - Myler C
AD  - Department of Anesthesiology and Perioperative Medicine, Penn State Health, 
      Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
LA  - eng
PT  - Case Reports
DEP - 20211101
PL  - United States
TA  - Case Rep Anesthesiol
JT  - Case reports in anesthesiology
JID - 101581025
PMC - PMC8575615
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/11/12 06:00
MHDA- 2021/11/12 06:01
PMCR- 2021/11/01
CRDT- 2021/11/11 06:57
PHST- 2021/03/07 00:00 [received]
PHST- 2021/10/13 00:00 [accepted]
PHST- 2021/11/11 06:57 [entrez]
PHST- 2021/11/12 06:00 [pubmed]
PHST- 2021/11/12 06:01 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - 10.1155/2021/9914311 [doi]
PST - epublish
SO  - Case Rep Anesthesiol. 2021 Nov 1;2021:9914311. doi: 10.1155/2021/9914311. 
      eCollection 2021.