PMID- 34760427
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211112
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 10
DP  - 2021 Oct
TI  - Cushing's Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple 
      Endocrine Neoplasia Type 1 Syndrome.
PG  - e18590
LID - 10.7759/cureus.18590 [doi]
LID - e18590
AB  - Multiple endocrine neoplasia type 1 (MEN 1) syndrome is characterized by 
      endocrinopathies and could be associated with thymic neuroendocrine tumors (NET). 
      On rare occasions, they can be functional adrenocorticotropic hormone-secreting 
      thymic carcinoid leading to Cushing's syndrome. In this report, we describe a 
      case of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome due to a 
      thymic NET associated with MEN type 1 syndrome. We highlight its aggressive 
      clinical course, the premise for a high index of suspicion for an ectopic ACTH 
      secretion, and the need for early surgical resection combined with medical 
      therapy and alternative treatments.
CI  - Copyright (c) 2021, Asemota et al.
FAU - Asemota, Iriagbonse R
AU  - Asemota IR
AD  - Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
FAU - Ajiboye, Oyintayo
AU  - Ajiboye O
AD  - Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
FAU - Nwaichi, Chineme
AU  - Nwaichi C
AD  - Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
FAU - Mbachi, Chimezie
AU  - Mbachi C
AD  - Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
FAU - Mba, Benjamin
AU  - Mba B
AD  - Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
LA  - eng
PT  - Case Reports
DEP - 20211007
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8572323
OTO - NOTNLM
OT  - acth secreting tumor
OT  - cushing syndrome
OT  - functional neuroendocrine tumor
OT  - men 1
OT  - mutiple endocrine neoplasia type
OT  - net
OT  - neuroendocrine tumor
OT  - thymic tumor
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/11/12 06:00
MHDA- 2021/11/12 06:01
PMCR- 2021/10/07
CRDT- 2021/11/11 06:57
PHST- 2020/05/28 00:00 [received]
PHST- 2021/10/07 00:00 [accepted]
PHST- 2021/11/11 06:57 [entrez]
PHST- 2021/11/12 06:00 [pubmed]
PHST- 2021/11/12 06:01 [medline]
PHST- 2021/10/07 00:00 [pmc-release]
AID - 10.7759/cureus.18590 [doi]
PST - epublish
SO  - Cureus. 2021 Oct 7;13(10):e18590. doi: 10.7759/cureus.18590. eCollection 2021 
      Oct.