PMID- 34761857
OWN - NLM
STAT- MEDLINE
DCOM- 20220104
LR  - 20220104
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jan
TI  - Role of aripiprazole in the management of behavioural and psychological symptoms 
      of dementia: a narrative review.
PG  - 137-144
LID - 10.1111/psyg.12787 [doi]
AB  - Behavioural and psychological symptoms of dementia affect in a great way quality 
      of life of both patients and their caregivers, which increases the risk of 
      patient institutionalisation when such symptoms are poorly controlled. One of the 
      drugs that are used for controlling behavioural and psychological symptoms of 
      dementia (BPSD) is aripiprazole. This narrative review aims to solve three basic 
      questions. Is aripiprazole useful for the management of these symptoms? Does 
      aripiprazole play a substantial role regarding safety and efficacy, compared with 
      the other pharmacological options available for the same purpose? Has 
      aripiprazole gained importance in treatment regimens of these symptoms, in 
      current clinical practice? We conclude that aripiprazole is effective to manage 
      BPSD. Moreover, it has shown a good safety profile compared with other 
      antipsychotics in advanced disease and frail patients. Thus, aripiprazole has 
      gained importance in current management algorithms for dementia patients mainly 
      due to its efficacy regarding rapid control of agitation and aggressiveness.
CI  - (c) 2021 Japanese Psychogeriatric Society.
FAU - Alvarez-Fernandez, Baldomero
AU  - Alvarez-Fernandez B
AD  - Geriatrics Unit, Department of Internal Medicine, Regional University Hospital of 
      Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), University of 
      Malaga, Malaga, Spain.
FAU - Bernal-Lopez, M Rosa
AU  - Bernal-Lopez MR
AUID- ORCID: 0000-0002-0238-0890
AD  - Geriatrics Unit, Department of Internal Medicine, Regional University Hospital of 
      Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), University of 
      Malaga, Malaga, Spain.
AD  - CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos 
      III, Madrid, Spain.
FAU - Gomez-Huelgas, Ricardo
AU  - Gomez-Huelgas R
AD  - Geriatrics Unit, Department of Internal Medicine, Regional University Hospital of 
      Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), University of 
      Malaga, Malaga, Spain.
AD  - CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos 
      III, Madrid, Spain.
LA  - eng
GR  - CB06/03/0018/Centros de Investigacion En Red/
GR  - C1- 0005-2020/Fondo Europeo de Desarrollo Regional-FEDER and Nicolas Monardes 
      Program/
GR  - CPII/00014/Miguel Servet Type II Program, Fondo Europeo de Desarrollo 
      Regional-FEDER/
PT  - Journal Article
PT  - Review
DEP - 20211110
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
RN  - 0 (Antipsychotic Agents)
RN  - 82VFR53I78 (Aripiprazole)
SB  - IM
MH  - Aggression
MH  - *Antipsychotic Agents/therapeutic use
MH  - Aripiprazole/therapeutic use
MH  - *Dementia/drug therapy
MH  - Humans
MH  - Quality of Life
OTO - NOTNLM
OT  - Alzheimer
OT  - antipsychotic
OT  - aripiprazole
OT  - behavioural disorder
OT  - dementia
OT  - psychosis
EDAT- 2021/11/12 06:00
MHDA- 2022/01/05 06:00
CRDT- 2021/11/11 08:44
PHST- 2021/10/13 00:00 [revised]
PHST- 2021/07/21 00:00 [received]
PHST- 2021/10/26 00:00 [accepted]
PHST- 2021/11/12 06:00 [pubmed]
PHST- 2022/01/05 06:00 [medline]
PHST- 2021/11/11 08:44 [entrez]
AID - 10.1111/psyg.12787 [doi]
PST - ppublish
SO  - Psychogeriatrics. 2022 Jan;22(1):137-144. doi: 10.1111/psyg.12787. Epub 2021 Nov 
      10.