PMID- 34763463
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20220531
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 10
DP  - 2021 Oct
TI  - Serum leukocyte cell-derived chemotaxin 2 level is associated with atopic 
      dermatitis patients.
PG  - 11006-11012
LID - 10.21037/apm-21-2690 [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a chronic skin inflammation with a 
      heterogeneous immunological profile. Leukocyte cell-derived chemotaxin 2 (LECT2) 
      is a liver-derived multifunctional cytokine that has been studied due to its 
      important role in inflammatory and autoimmune diseases. However, the relationship 
      between AD and LECT2 has not been defined. This study was performed to 
      investigate the levels of LECT2 in patients with AD and to determine whether it 
      was associated with the severity and clinical characteristics of AD. METHODS: The 
      study included 42 AD patients and 30 healthy controls from the Affiliated 
      Hospital of Medical School of Ningbo University. Participants' serum levels of 
      LECT2 were measured using enzyme-linked immunosorbent assay kits. The values in 
      the patient group and control group were statistically compared. The 
      relationships between the different markers were evaluated by correlation 
      analysis. RESULTS: The serum levels of LECT2 were significantly higher in AD 
      patients than those in the controls. In addition, LECT2 was significantly 
      correlated with the Scoring of Atopic Dermatitis (SCORAD) index, the level of 
      immunoglobulin E (IgE), and eosinophils (P<0.01, for all 3). CONCLUSIONS: Serum 
      LECT2 levels were evaluated in AD patients. The results showed that LECT2 may be 
      a useful biomarker of AD, and may participate in the occurrence and regulation of 
      inflammation in AD progression.
FAU - Zhao, Keyu
AU  - Zhao K
AD  - Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China; Central Laboratory, The Affiliated Hospital of Medical 
      School, Ningbo University, Ningbo, China.
FAU - Xu, Feng
AU  - Xu F
AD  - Central Laboratory, The Affiliated Hospital of Medical School, Ningbo University, 
      Ningbo, China; State Key Laboratory for Managing Biotic and Chemical Threats to 
      the Quality and Safety of Agro-products, Ningbo University, Ningbo, China.
FAU - Jiang, Xinyu
AU  - Jiang X
AD  - Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China; Central Laboratory, The Affiliated Hospital of Medical 
      School, Ningbo University, Ningbo, China.
FAU - Chen, Jiong
AU  - Chen J
AD  - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and 
      Safety of Agro-products, Ningbo University, Ningbo, China; Laboratory of 
      Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, 
      Ningbo University, Ningbo, China.
FAU - Zhu, Xiaoxia
AU  - Zhu X
AD  - Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China.
FAU - Zhou, Qiongyan
AU  - Zhou Q
AD  - Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China.
FAU - Xu, Suling
AU  - Xu S
AD  - Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 0 (Biomarkers)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (LECT2 protein, human)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Biomarkers
MH  - Chemotactic Factors
MH  - *Dermatitis, Atopic/blood
MH  - Eosinophils
MH  - Humans
MH  - Immunoglobulin E
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Leukocyte Count
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Atopic dermatitis (AD)
OT  - cytokines
OT  - inflammatory factors
OT  - leukocyte cell-derived chemotaxin 2 (LECT2)
EDAT- 2021/11/13 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/11/12 05:27
PHST- 2021/09/02 00:00 [received]
PHST- 2021/10/16 00:00 [accepted]
PHST- 2021/11/12 05:27 [entrez]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
AID - 10.21037/apm-21-2690 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Oct;10(10):11006-11012. doi: 10.21037/apm-21-2690.