PMID- 3476350
OWN - NLM
STAT- MEDLINE
DCOM- 19871013
LR  - 20210915
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 116
IP  - 4
DP  - 1987 Aug
TI  - Disequilibrium pattern analysis. II. Application to Danish HLA A and B locus 
      data.
PG  - 633-43
AB  - Disequilibrium pattern analysis, a general method for analyzing evolutionary 
      events acting on pairs of tightly linked polymorphic loci, is applied to a large 
      sample of Danish individuals typed for A and B loci of the HLA (human leukocyte 
      antigen) system. Cases of selection on particular haplotypes are revealed from 
      patterns of linkage disequilibrium among the HLA haplotypes. These patterns 
      cannot be explained by either population admixture or random genetic drift. Six 
      haplotypes out of the total array of 273 haplotypes have been identified which 
      show in varying extents the patterns indicating selection.
FAU - Klitz, W
AU  - Klitz W
FAU - Thomson, G
AU  - Thomson G
LA  - eng
GR  - GM35326/GM/NIGMS NIH HHS/United States
GR  - HD12731/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Biological Evolution
MH  - Denmark
MH  - *Genetic Linkage
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - *Haplotypes
MH  - Humans
MH  - *Major Histocompatibility Complex
MH  - *Models, Genetic
MH  - Polymorphism, Genetic
PMC - PMC1203176
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
PMCR- 1987/11/01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
PHST- 1987/11/01 00:00 [pmc-release]
AID - 10.1093/genetics/116.4.633 [doi]
PST - ppublish
SO  - Genetics. 1987 Aug;116(4):633-43. doi: 10.1093/genetics/116.4.633.