PMID- 34764662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, 
      rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with 
      Type 2 Diabetes in Xinjiang.
PG  - 4443-4450
LID - 10.2147/DMSO.S305831 [doi]
AB  - BACKGROUND: The Wnt signaling pathway plays a valuable role in bone metabolism. 
      SOST is a major inhibitor of the Wnt signaling pathway. The expression of SOST 
      and genetic polymorphism might be associated with bone mineral density in 
      postmenopausal women with type 2 diabetes mellitus (T2DM). OBJECTIVE: This study 
      aims to explore whether SOST protein expression and genetic locus rs851056, 
      rs1230399 polymorphism is associated with bone mineral density in postmenopausal 
      women with T2DM in Xinjiang. METHODS: A total of 136 Xinjiang postmenopausal 
      women were divided into four groups: A (-/-), B (+/-), C (-/+), and D (+/+) by 
      assessing their OGTT and bone mass. Genetic polymorphisms were determined using 
      the mass ARRAY mass spectrometer. RESULTS: 1) Genotypes and allele frequencies at 
      rs851056 were statistically significant differences in groups B and D patients 
      compared to group A, respectively. 2) Individuals carrying the GG genotype had 
      lower HDL, Ca, and ALP as compared to those carrying the GC/CC genotypes in group 
      C. In contrast, individuals carrying the GG genotype had higher BMD (L1-4) as 
      compared to those carrying the GC/CC genotypes in group D. 3) SOST protein 
      expression levels were higher in groups C and D than in group A. 4). BMD (L1-4) 
      was negatively correlated with SOST protein. 5) Multiple linear regression 
      analysis for BMD-dependent variables showed that the decrease of BMI and TG were 
      risk factors for BMD (L1-4), besides, the decrease of BMI, ALP, and extended 
      years of menopause were all risk factors for BMD (femoral neck). CONCLUSION: SOST 
      protein expression and genetic locus rs851056, rs1230399 polymorphism are 
      associated with bone mineral density in postmenopausal women with type 2 diabetes 
      mellitus in Xinjiang.
CI  - (c) 2021 Li et al.
FAU - Li, Jun
AU  - Li J
AD  - Endocrinology and Metabolism Department, First Affiliated Hosptital, School of 
      Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People's 
      Republic of China.
FAU - Ren, YanXia
AU  - Ren Y
AD  - Endocrinology and Metabolism Department, First Affiliated Hosptital, School of 
      Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People's 
      Republic of China.
FAU - Li, SiYuan
AU  - Li S
AD  - Shihezi University School of Medicine, Shihezi, Xinjiang Uygur Autonomous Region, 
      People's Republic of China.
FAU - Li, JiaJia
AU  - Li J
AD  - Endocrinology and Metabolism Department, Second People's Hospital of Nanyang, 
      Nanyang, Henan Province, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20211104
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8575445
OTO - NOTNLM
OT  - SOST gene polymorphism
OT  - SOST protein
OT  - bone mineral density
OT  - gene mutation
OT  - osteoporosis
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests in this work.
EDAT- 2021/11/13 06:00
MHDA- 2021/11/13 06:01
PMCR- 2021/11/04
CRDT- 2021/11/12 06:58
PHST- 2021/02/12 00:00 [received]
PHST- 2021/10/01 00:00 [accepted]
PHST- 2021/11/12 06:58 [entrez]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2021/11/13 06:01 [medline]
PHST- 2021/11/04 00:00 [pmc-release]
AID - 305831 [pii]
AID - 10.2147/DMSO.S305831 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Nov 4;14:4443-4450. doi: 10.2147/DMSO.S305831. 
      eCollection 2021.