PMID- 34764814
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211113
IS  - 1426-3912 (Print)
IS  - 1644-4124 (Electronic)
IS  - 1426-3912 (Linking)
VI  - 46
IP  - 3
DP  - 2021
TI  - Alpha-gal syndrome: the first report in Poland.
PG  - 398-400
LID - 10.5114/ceji.2021.108766 [doi]
AB  - Alpha-gal syndrome is an immunoglobulin E (IgE)-dependent allergy to 
      galactose-alpha-1,3-galactose, resulting in a delayed anaphylactic reaction to red 
      meat. The syndrome is causally linked to bites from ticks and associated with 
      cross-reactivity to some drugs, e.g. cetuximab. Although cases of alpha-gal 
      allergy have already been reported in a few European countries, to our best 
      knowledge, no cases have been reported so far in Central-Eastern Europe. In the 
      current report, we describe a case of alpha-gal syndrome diagnosed in Poland, to 
      highlight the fact that it may occur in new geographic areas. Within three 
      months, the described patient underwent five anaphylactic reactions with typical 
      clinical manifestations. They developed a few hours after ingestion of red meat 
      (pork, beef or mutton) and were preceded by tick bites. The level of specific IgE 
      antibodies to alpha-gal reached 72.6 kAU/l, whereas the levels of specific IgE 
      antibodies to other food allergens were within the reference range. As the onset 
      of symptoms in this syndrome is usually delayed, numerous cases may be identified 
      as idiopathic anaphylaxis, while early diagnosis is indispensable to avoid 
      potentially life-threatening complications.
CI  - Copyright (c) 2021 Termedia.
FAU - Brzozowska, Mirella
AU  - Brzozowska M
AD  - Department of Skin and Venereal Diseases, Clinical Hospital of the Pomeranian 
      Medical University, Police, Poland.
FAU - Mokrzycka, Natalia
AU  - Mokrzycka N
AD  - Jagiellonian University Medical College, Krakow, Poland.
FAU - Porebski, Grzegorz
AU  - Porebski G
AD  - Department of Clinical and Environmental Allergology, Jagiellonian University 
      Medical College, Krakow, Poland.
LA  - eng
PT  - Case Reports
DEP - 20210828
PL  - Poland
TA  - Cent Eur J Immunol
JT  - Central-European journal of immunology
JID - 9702239
PMC - PMC8574113
OTO - NOTNLM
OT  - allergy
OT  - alpha-gal syndrome
OT  - anaphylaxis
EDAT- 2021/11/13 06:00
MHDA- 2021/11/13 06:01
PMCR- 2021/01/01
CRDT- 2021/11/12 06:59
PHST- 2020/08/26 00:00 [received]
PHST- 2021/02/16 00:00 [accepted]
PHST- 2021/11/12 06:59 [entrez]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2021/11/13 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 45048 [pii]
AID - 10.5114/ceji.2021.108766 [doi]
PST - ppublish
SO  - Cent Eur J Immunol. 2021;46(3):398-400. doi: 10.5114/ceji.2021.108766. Epub 2021 
      Aug 28.