PMID- 34764846
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211113
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Prediction of Deep Brain Stimulation Outcome in Parkinson's Disease With 
      Connectome Based on Hemispheric Asymmetry.
PG  - 620750
LID - 10.3389/fnins.2021.620750 [doi]
LID - 620750
AB  - Parkinson's disease (PD) is a neurodegenerative disease that is associated with 
      motor and non-motor symptoms and caused by lack of dopamine in the substantia 
      nigra of the brain. Subthalamic nucleus deep brain stimulation (STN-DBS) is a 
      widely accepted therapy of PD that mainly inserts electrodes into both sides of 
      the brain. The effect of STN-DBS was mainly for motor function, so this study 
      focused on the recovery of motor function for PD after DBS. Hemispherical 
      asymmetry in the brain network is considered to be a potential indicator for 
      diagnosing PD patients. This study investigated the value of hemispheric brain 
      connection asymmetry in predicting the DBS surgery outcome in PD patients. Four 
      types of brain connections, including left intra-hemispheric (LH) connection, 
      right intra-hemispheric (RH) connection, inter-hemispheric homotopic (Ho) 
      connection, and inter-hemispheric heterotopic (He) connection, were constructed 
      based on the resting state functional magnetic resonance imaging (rs-fMRI) 
      performed before the DBS surgery. We used random forest for selecting features 
      and the Ridge model for predicting surgical outcome (i.e., improvement rate of 
      motor function). The functional connectivity analysis showed that the brain has a 
      right laterality: the RH networks has the best correlation (r = 0.37, p = 
      5.68E-03) between the predicted value and the true value among the above four 
      connections. Moreover, the region-of-interest (ROI) analysis indicated that the 
      medioventral occipital cortex (MVOcC)-superior temporal gyrus (STG) and thalamus 
      (Tha)-precentral gyrus (PrG) contributed most to the outcome prediction model for 
      DBS without medication. This result provides more support for PD patients to 
      evaluate DBS before surgery.
CI  - Copyright (c) 2021 Wang, Shang, He, Zhou, Chen, Ma and Li.
FAU - Wang, Jingqi
AU  - Wang J
AD  - School of Computer Science and Technology, Beijing Institute of Technology, 
      Beijing, China.
FAU - Shang, Ruihong
AU  - Shang R
AD  - School of Computer Science and Technology, Beijing Institute of Technology, 
      Beijing, China.
FAU - He, Le
AU  - He L
AD  - Department of Biomedical Engineering, Center for Biomedical Imaging Research, 
      School of Medicine, Tsinghua University, Beijing, China.
FAU - Zhou, Rongsong
AU  - Zhou R
AD  - Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China.
FAU - Chen, Zhensen
AU  - Chen Z
AD  - Department of Radiology, University of Washington, Seattle, WA, United States.
FAU - Ma, Yu
AU  - Ma Y
AD  - Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China.
FAU - Li, Xuesong
AU  - Li X
AD  - School of Computer Science and Technology, Beijing Institute of Technology, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20211026
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8576048
OTO - NOTNLM
OT  - Parkinson's disease
OT  - functional connectivity
OT  - hemispheric asymmetry
OT  - important feature
OT  - improvement of motor function
OT  - resting state functional magnetic resonance imaging (rfMRI)
OT  - subthalamic nucleus deep brain stimulation (STN-DBS)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/13 06:00
MHDA- 2021/11/13 06:01
PMCR- 2021/01/01
CRDT- 2021/11/12 07:00
PHST- 2020/10/27 00:00 [received]
PHST- 2021/09/28 00:00 [accepted]
PHST- 2021/11/12 07:00 [entrez]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2021/11/13 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.620750 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Oct 26;15:620750. doi: 10.3389/fnins.2021.620750. 
      eCollection 2021.