PMID- 34764850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211113
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Identifying Type 2 Diabetic Brains by Investigating Disease-Related Structural 
      Changes in Magnetic Resonance Imaging.
PG  - 728874
LID - 10.3389/fnins.2021.728874 [doi]
LID - 728874
AB  - Diabetes with high blood glucose levels may damage the brain nerves and thus 
      increase the risk of dementia. Previous studies have shown that dementia can be 
      reflected in altered brain structure, facilitating computer-aided diagnosis of 
      brain diseases based on structural magnetic resonance imaging (MRI). However, 
      type 2 diabetes mellitus (T2DM)-mediated changes in the brain structures have not 
      yet been studied, and only a few studies have focused on the use of brain MRI for 
      automated diagnosis of T2DM. Hence, identifying MRI biomarkers is essential to 
      evaluate the association between changes in brain structure and T2DM as well as 
      cognitive impairment (CI). The present study aims to investigate four methods to 
      extract features from MRI, characterize imaging biomarkers, as well as identify 
      subjects with T2DM and CI.
CI  - Copyright (c) 2021 Chen, Pan, Kang, Lu, Tan, Liang, Lyu, Li, Huang, Qin, Zhu, Li 
      and Qiu.
FAU - Chen, Yuna
AU  - Chen Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, China.
AD  - Postdoctoral Research Station, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Pan, Yongsheng
AU  - Pan Y
AD  - School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
AD  - School of Computer Science and Engineering, Northwestern Polytechnical 
      University, Xi'an, China.
FAU - Kang, Shangyu
AU  - Kang S
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Lu, Junshen
AU  - Lu J
AD  - Guangxi School of Traditional Chinese Medicine, Nanning, China.
FAU - Tan, Xin
AU  - Tan X
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Liang, Yi
AU  - Liang Y
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Lyu, Wenjiao
AU  - Lyu W
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Li, Yifan
AU  - Li Y
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Huang, Haoming
AU  - Huang H
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qin, Chunhong
AU  - Qin C
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Zhu, Zhangzhi
AU  - Zhu Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, China.
FAU - Li, Saimei
AU  - Li S
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20211026
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8576452
OTO - NOTNLM
OT  - cognitive impairment
OT  - machine learning
OT  - medical image
OT  - structural MRI
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/13 06:00
MHDA- 2021/11/13 06:01
PMCR- 2021/01/01
CRDT- 2021/11/12 07:00
PHST- 2021/06/22 00:00 [received]
PHST- 2021/10/04 00:00 [accepted]
PHST- 2021/11/12 07:00 [entrez]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2021/11/13 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.728874 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Oct 26;15:728874. doi: 10.3389/fnins.2021.728874. 
      eCollection 2021.