PMID- 34766359
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 45
IP  - 2
DP  - 2022 Feb
TI  - Left bundle branch pacing in heart failure patients with left bundle branch 
      block: A systematic review and meta-analysis.
PG  - 212-218
LID - 10.1111/pace.14405 [doi]
AB  - BACKGROUND: The clinical benefit of cardiac resynchronization therapy (CRT) in 
      heart failure patients with left bundle branch block (LBBB) has been 
      demonstrated. However, a nonresponse rate of CRT nearly 1/3. Recent studies have 
      reported left bundle branch pacing (LBBP) has achieved remarkable effect in CRT. 
      This study aim to explore the efficacy and safety of LBBP in heart failure 
      patients with LBBB. METHODS: We searched PubMed, Cochrane Library, Web of 
      science, and CNKI databases for studies about LBBP in heart failure patients with 
      LBBB. QRS duration (QRSd), New York Heart Association (NYHA) classification, 
      B-type natriuretic peptide (BNP) concentration, left ventricular ejection 
      fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), pacing 
      threshold and other related data were extracted and summarized. RESULTS: A total 
      of 6 studies were included, and the success rate of LBBP was 93.2%. Compared with 
      baseline, LBBP could shorten QRSd (MD = 61.23, 95% CI: 58.21-64.25, p < .01). 
      Echocardiographic parameters including LVEF and LVEDD significantly improved 
      (both with p < .01). Clinical outcomes including NYHA classification and BNP 
      dramatically reduced (both with p < .01). Compared with biventricular pacing 
      (BVP), LBBP could further improve QRSd, LVEF, LVEDD, and NYHA classification (all 
      with p < .01). However, the pacing threshold at follow-up was 0.06 V higher than 
      that at baseline (p < .01), and the incidence of complications was 2.4%. 
      CONCLUSIONS: LBBP is effective and safe in heart failure patients with LBBB, 
      whether it is better than BVP needs to be verified by randomized controlled 
      trials.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Cheng, Yuda
AU  - Cheng Y
AUID- ORCID: 0000-0002-3251-9507
AD  - Department of Cardiology, Affiliated Hospital of Hebei University, YuHua street, 
      Baoding, Hebei, 071000, China.
FAU - Wang, Zhanqi
AU  - Wang Z
AD  - Department of Cardiology, Affiliated Hospital of Hebei University, YuHua street, 
      Baoding, Hebei, 071000, China.
FAU - Li, Yujun
AU  - Li Y
AD  - Department of Cardiology, Affiliated Hospital of Hebei University, YuHua street, 
      Baoding, Hebei, 071000, China.
FAU - Qi, Jinlei
AU  - Qi J
AUID- ORCID: 0000-0003-4937-2123
AD  - Department of Cardiology, Affiliated Hospital of Hebei University, YuHua street, 
      Baoding, Hebei, 071000, China.
FAU - Liu, Jinyu
AU  - Liu J
AD  - Department of Cardiology, Affiliated Hospital of Hebei University, YuHua street, 
      Baoding, Hebei, 071000, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220117
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Bundle-Branch Block/complications/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Heart Failure/complications/*therapy
MH  - Humans
OTO - NOTNLM
OT  - biventricular pacing
OT  - cardiac resynchronization therapy
OT  - heart failure
OT  - left bundle branch block
OT  - left bundle branch pacing
EDAT- 2021/11/13 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/11/12 07:22
PHST- 2021/10/22 00:00 [revised]
PHST- 2021/07/22 00:00 [received]
PHST- 2021/11/07 00:00 [accepted]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/11/12 07:22 [entrez]
AID - 10.1111/pace.14405 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2022 Feb;45(2):212-218. doi: 10.1111/pace.14405. Epub 
      2022 Jan 17.