PMID- 34766696 OWN - NLM STAT- MEDLINE DCOM- 20220321 LR - 20230308 IS - 1467-789X (Electronic) IS - 1467-7881 (Print) IS - 1467-7881 (Linking) VI - 23 Suppl 1 IP - Suppl 1 DP - 2022 Jan TI - Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies. PG - e13383 LID - 10.1111/obr.13383 [doi] AB - We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], and polychlorinated biphenyls [PCBs]), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and polybrominated diphenyl ethers (PBDEs) that are the POPs more widely studied in environmental birth cohorts so far. We search two databases (PubMed and Embase) through July/09/2021 and identified 33 studies reporting associations with prenatal organochlorine exposure, 21 studies reporting associations with prenatal PFAS, and five studies reporting associations with prenatal PBDEs. We conducted a qualitative review. Additionally, we performed random-effects meta-analyses of POP exposures, with data estimates from at least three prospective studies, and BMI-z. Prenatal DDE and HCB levels were associated with higher BMI z-score in childhood (beta: 0.12, 95% CI: 0.03, 0.21; I(2) : 28.1% per study-specific log increase of DDE and beta: 0.31, 95% CI: 0.09, 0.53; I(2) : 31.9% per study-specific log increase of HCB). No significant associations between PCB-153, PFOA, PFOS, or pentaPBDEs with childhood BMI were found in meta-analyses. In individual studies, there was inconclusive evidence that POP levels were positively associated with other obesity indicators (e.g., waist circumference). CI - (c) 2021 World Obesity Federation. FAU - Stratakis, Nikos AU - Stratakis N AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - Rock, Sarah AU - Rock S AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - La Merrill, Michele A AU - La Merrill MA AD - Department of Environmental Toxicology, University of California, Davis, California, USA. FAU - Saez, Marc AU - Saez M AD - Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain. AD - CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Robinson, Oliver AU - Robinson O AUID- ORCID: 0000-0002-4735-0468 AD - MRC Centre for Environment and Health, Imperial College London, London, UK. FAU - Fecht, Daniela AU - Fecht D AD - UK Small Area Health Statistics Unit, MRC Centre for Environment and Health, Imperial College London, London, UK. FAU - Vrijheid, Martine AU - Vrijheid M AD - CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. FAU - Valvi, Damaskini AU - Valvi D AD - Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Conti, David V AU - Conti DV AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - McConnell, Rob AU - McConnell R AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - Chatzi, Vaia Lida AU - Chatzi VL AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. LA - eng GR - R21 ES029681/ES/NIEHS NIH HHS/United States GR - P30DK048522/NH/NIH HHS/United States GR - R01 ES030691/ES/NIEHS NIH HHS/United States GR - P30ES007048/ES/NIEHS NIH HHS/United States GR - P30 ES023515/ES/NIEHS NIH HHS/United States GR - R01 ES030364/ES/NIEHS NIH HHS/United States GR - P30 DK048522/DK/NIDDK NIH HHS/United States GR - MR/S019669/1/MRC_/Medical Research Council/United Kingdom GR - P01 CA196569/CA/NCI NIH HHS/United States GR - R01ES030691/ES/NIEHS NIH HHS/United States GR - R01 ES029944/ES/NIEHS NIH HHS/United States GR - P30 ES007048/ES/NIEHS NIH HHS/United States GR - R01CA140561/NH/NIH HHS/United States GR - P01CA196569/NH/NIH HHS/United States GR - R01ES030364/ES/NIEHS NIH HHS/United States GR - R21 ES028903/ES/NIEHS NIH HHS/United States GR - R01 ES016813/ES/NIEHS NIH HHS/United States GR - R21 ES029328/ES/NIEHS NIH HHS/United States GR - R01 CA140561/CA/NCI NIH HHS/United States GR - R01ES029944/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Meta-Analysis PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Systematic Review DEP - 20211112 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Child MH - *Environmental Pollutants/adverse effects MH - Female MH - Humans MH - *Pediatric Obesity/epidemiology/etiology MH - Persistent Organic Pollutants MH - *Polychlorinated Biphenyls/adverse effects MH - Pregnancy MH - *Prenatal Exposure Delayed Effects MH - Prospective Studies PMC - PMC9512275 MID - NIHMS1835277 OTO - NOTNLM OT - childhood, STOP project OT - obesity OT - persistent organic pollutants EDAT- 2021/11/13 06:00 MHDA- 2022/03/22 06:00 PMCR- 2022/09/26 CRDT- 2021/11/12 08:49 PHST- 2021/10/09 00:00 [received] PHST- 2021/10/11 00:00 [accepted] PHST- 2021/11/13 06:00 [pubmed] PHST- 2022/03/22 06:00 [medline] PHST- 2021/11/12 08:49 [entrez] PHST- 2022/09/26 00:00 [pmc-release] AID - 10.1111/obr.13383 [doi] PST - ppublish SO - Obes Rev. 2022 Jan;23 Suppl 1(Suppl 1):e13383. doi: 10.1111/obr.13383. Epub 2021 Nov 12.